Title:
【発明の名称】平滑筋細胞増殖のインヒビターとしての硫酸化多糖類
Document Type and Number:
Japanese Patent JPH06506973
Kind Code:
A
Abstract:
Highly sulfated oligosaccharides in the form of hexasaccharide and octasaccharide compounds which have antiproliferative activity with respect to smooth muscle cells are useful in treatment of conditions characterized by unwanted smooth muscle cell proliferation such as a result of trauma or disease states such as asthma, congestive heart failure and hypertension. The oligosaccharides have increased ability to inhibit the proliferation of smooth muscle cells and decreased ability to act as an anticoagulant as compared with commercial heparin and/or unseparated fragments of heparin.
Inventors:
Conrad, H. Edward
Fugedi, Peter
Brand Ray, Brian Kay.
Rum, Lung H.
Rain, Roger A.
Fugedi, Peter
Brand Ray, Brian Kay.
Rum, Lung H.
Rain, Roger A.
Application Number:
JP51089092A
Publication Date:
August 04, 1994
Filing Date:
April 15, 1992
Export Citation:
Assignee:
Glycomed Incorporated
International Classes:
C07H11/00; A61K31/715; A61P43/00; C07H3/06; C07H17/04; C08B37/00; C08B37/10; (IPC1-7): C08B37/10; A61K31/725; C07H11/00
Attorney, Agent or Firm:
Shusaku Yamamoto