Title:
【発明の名称】改善された官能性を有するテキサフィリン金属錯体
Document Type and Number:
Japanese Patent JPH10500659
Kind Code:
A
Abstract:
Texaphyrin metal complexes having improved functionalization include the addition of electron-donating groups to positions 2, 7, 12, 15, 18 and/or 21 and/or the addition of electron-withdrawing groups to positions 15 and/or 18 of the macrocycle. Electron-donating groups at positions 2, 7, 12, 15, 18 and/or 21 contribute electrons to the aromatic pi system of the macrocycle which stabilizes the metal complex to demetallation and the imine bonds to hydrolysis. The addition of substituents to the 12 and 21 positions of the macrocycle offer steric protection for the imine bonds against possible in vivo enzyme hydrolysis. Electron-withdrawing groups at positions 15 and/or 18 render the macrocycle more readily reduced, i.e. the redox potential is lower and the macrocycle more readily gains an electron to form a radical. Such texaphyrins having a low redox potential and imine bond stabilization are useful in a variety of applications.
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Inventors:
Sessler, Jonathan El
Modi, Tarak Dee
Henmi, Gregory W
Modi, Tarak Dee
Henmi, Gregory W
Application Number:
JP52143495A
Publication Date:
January 20, 1998
Filing Date:
February 15, 1995
Export Citation:
Assignee:
Board Of Regents, The University Of Texas System
Pharma Cyclos, Inc.
Pharma Cyclos, Inc.
International Classes:
A61K31/40; A61K41/00; A61K47/48; A61K49/00; A61K49/06; A61K49/08; A61K51/00; A61K51/04; A61L2/00; A61P35/00; C07D487/22; C07H21/00; (IPC1-7): C07D487/22; A61K31/40; A61K49/00; A61K51/00
Attorney, Agent or Firm:
Nao Okuyama (3 others)