Title:
【発明の名称】フェニレンジアミン基を含む、アルファ-メチルベンジル-含有の、ヘルペスウイルスのチオ尿素インヒビター
Document Type and Number:
Japanese Patent JP2002531555
Kind Code:
A
Abstract:
Compounds having formula (I) wherein R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen,-CN,-NO2,-CO2R6,-COR6,-OR6,-SR6,-SOR6,-SO2R6,-CONR7R8,-NR6N(R7R8),-N(R7R8) or W-Y-(CH2)n-Z provided that at least one of R1-R5 is not hydrogen; or R2 and R3, or R3 and R4, taken together to form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together may form a 3 to 7 membered heterocycloalkyl; W is O, NR6, or is absent; Y is -(CO)- or-(CO2)-, or is absent; Z is alkyl of 1 to 4 carbon atoms,-CN,-CO2R6, COR6,-CONR7R8,-OCOR6,-NR6COR7,-OCONR6,-OR6,-SR6,-SOR6,-SO2R6, SR6N(R7R8),-N(R7R8) or phenyl; G is aryl or fused bicyclic heteroaryl; X is a bond,-NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and-7, and Kaposi herpesvirus.
Inventors:
Bloom, Jonathan David
Karan, Kevin J. Joseph
Day Grande, Martin Joseph
Dassin, Russell Giyogi
Lang, Stanley Albert
Norton, Emily Boucher
Ross, Adma Antonia
O'Hara, Brian Mark
Karan, Kevin J. Joseph
Day Grande, Martin Joseph
Dassin, Russell Giyogi
Lang, Stanley Albert
Norton, Emily Boucher
Ross, Adma Antonia
O'Hara, Brian Mark
Application Number:
JP2000586707A
Publication Date:
September 24, 2002
Filing Date:
December 06, 1999
Export Citation:
Assignee:
Wyeth
International Classes:
A61K31/17; A61K31/18; A61K31/343; A61K31/47; A61K31/472; A61K31/4725; A61P31/22; C07C335/20; C07D215/48; C07D215/50; C07D215/54; C07D217/06; C07D217/26; C07D307/79; C07D307/81; C07D307/85; C07D405/12; C07D407/12; (IPC1-7): C07C335/20; A61K31/17; A61K31/18; A61K31/343; A61K31/47; A61K31/472; A61K31/4725; A61P31/22; C07D215/48; C07D215/50; C07D217/26; C07D307/79; C07D307/81; C07D307/85; C07D405/12; C07D407/12
Attorney, Agent or Firm:
Heiyoshi Odashima