【発明の名称】10―アルキル―10―デアザアミノプテリン化合物のジアステレオマー、それらの製造方法並びに白血病及び腹水腫瘍の治療のための製薬組成物

Title:

Document Type and Number:

Japanese Patent JPH089619

Kind Code:

B2

Abstract:

Diastereomers of 10-alkyl-10-deazaminopterins are provided, as well as a synthesis for their preparation as the individual d,L. and l,L.-diastereomers, the d,L-10-ethyl diastereomer being three times as potent against L1210 cells as the l,L-10-ethyl diastereomer, and the l,L-10-ethyl diastereomer being approximately one-half as toxic as the d,L-10-ethyl diastereomer.

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Inventors:

DeGrow, Joseph Eye
Christie, Pamela H
Shirotsunak, Francis M

Application Number:

JP50618686A

Publication Date:

January 31, 1996

Filing Date:

November 24, 1986

Export Citation:

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Assignee:

S-all eye interface
Memorial Sloan-Kettering Cancer Center

International Classes:

C07D475/00; A61K31/495; A61P29/00; A61P35/00; A61P35/02; C07D475/08; (IPC1-7): C07D475/08; A61K31/495

Domestic Patent References:

JPS5651482A

1981-05-09

Attorney, Agent or Firm:

Kawahara Kazuho

Next Patent: １Ｈ―ピラゾロ〔５，１―Ｃ〕―１，２，４―トリアゾール化合物の製造�...