Title:
【発明の名称】3,4-ジヒドロキシベンジル置換炭酸誘導体そして抗酸化剤としてのそれの使用
Document Type and Number:
Japanese Patent JP2003535915
Kind Code:
A
Abstract:
3,4-Dihydroxybenzyl-substituted carbonic acid derivatives (I) are new. Carbonic acid derivatives of formula (I) (including their tautomers) are new. [Image] X1-X3O, S or NR3; R1H, R4, OH or OR4; R4alkyl, alkenyl, 1-oxoalkyl or 1-oxoalkenyl (all having up to 5C); R2H, linear, branched or cyclic alkyl or alkenyl of 1-22C (in which at least one C is optionally replaced by O), or ring-substituted (but halogen-free) 7-15C aralkyl, and R3H, or linear, branched or cyclic alkyl or alkenyl of 1-22C (in which at least one C is optionally replaced by O). An independent claim is included for the preparation of (I). - ACTIVITY : Dermatological; Antioxidant. - MECHANISM OF ACTION : Radical scavenger. In radical scavenging tests using DPPH (1,1-diphenyl-2-picryl hydrazyl) as test radical, N-(3,4-dihydroxybenzyl)-N'-(n-hexyl)-thio urea (Ia) had an EC50 value of 0.06 mol/mol, compared with 0.27 mol/mol for vitamin C.
Inventors:
Rye, Jacob Peter
Jyeon Kotsk, William
Langner, Roland
Jyeon Kotsk, William
Langner, Roland
Application Number:
JP2002503677A
Publication Date:
December 02, 2003
Filing Date:
June 11, 2001
Export Citation:
Assignee:
Herman und Reimer Geselsyaft Mitt Besilyenktel Haftung
International Classes:
A01N1/00; A23L33/10; A61K8/00; A61K8/30; A61K8/33; A61K8/41; A61K8/44; A61K8/46; A61K8/49; A61K31/17; A61K31/27; A61K31/325; A61K47/08; A61K47/16; A61K47/18; A61K47/20; A61Q3/00; A61Q3/02; A61Q5/00; A61Q17/00; A61Q17/04; A61Q19/00; A61Q19/08; C07C269/04; C07C271/06; C07C271/16; C07C271/34; C07C275/10; C07C279/08; C07C279/10; C07C327/00; C07C333/04; C07C333/20; C07C335/00; C07C335/12; C09K15/04; C09K15/20; C09K15/24; C09K15/26; C09K15/28; (IPC1-7): C07C271/16; A23L1/30; A61K7/00; A61K7/04; A61K7/06; A61K7/48; C07C269/04; C07C333/04; C07C333/20; C07C335/12; C09K15/24; C09K15/28
Attorney, Agent or Firm:
Heiyoshi Odashima