Title:
【発明の名称】HLA連鎖子癇前症および流産感受性遺伝子
Document Type and Number:
Japanese Patent JP2003517267
Kind Code:
A
Abstract:
The invention relates to the identification of a susceptibility gene for pre-eclampsia and eclampsia and provides methods and diagnostic kits for diagnosing susceptibility to normal pregnancy, pre-eclampsia, eclampsia, intrauterine growth retardation, miscarriage or miscarriage-related infertility. The invention is based on analysing HLA-G or HLA-G linked nucleic acid, or HLA-G protein or HLA-G mRNA or cells or molecules whose concentration changes as a result of HLA-G action. The invention also provides pharmaceutical compositions for and methods of treatment of the above conditions.
Inventors:
O'Brien, Margaret
John Birmingham
Kwan, Kathleen A.
Jenkins, David M.
McCarthy, Tommy Buoy.
John Birmingham
Kwan, Kathleen A.
Jenkins, David M.
McCarthy, Tommy Buoy.
Application Number:
JP2000533590A
Publication Date:
May 27, 2003
Filing Date:
February 25, 1999
Export Citation:
Assignee:
National University of Ireland, Cork
International Classes:
A61K35/14; A61K38/00; A61K39/395; A61K45/00; A61P15/00; A61P15/06; A61P15/08; C12N5/10; C12N15/09; C12N15/12; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/564; G01N33/569; G01N33/68; (IPC1-7): C12N15/09; A61K35/14; A61K38/00; A61K39/395; A61K45/00; A61P15/00; A61P15/06; A61P15/08; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/564; G01N33/68
Attorney, Agent or Firm:
Shusaku Yamamoto