Title:
【発明の名称】N-保護アミンおよびそのプロドラッグとしての使用
Document Type and Number:
Japanese Patent JP2002543059
Kind Code:
A
Abstract:
Compounds of formula (I) or (II), wherein X represents H, C1-6 alkyl or C1-6 alkoxy, said alkyl or alkoxy being optionally substituted with one or more groups; a is 0,1,2,3 or 4; Y represents H or C1-6 alkyl; 1, 2 or 3 of the members Z of the 5-membered aromatic ring are independently selected from -O-, -S-, -N= or -NR-, where R is H or C1-6 alkyl optionally substituted with one or more of groups; and E represents a moiety such that EH is an amine; provided that in formula (I) if a = 0 then Y≠H, are provided along with a method of selecting desired protecting groups by measuring the fragmentation rates of compounds of formula (I) or (II) when the nitro group is selected.
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Inventors:
Denny, William, Alexander
Hay, michael, patrick
Wilson, william, robert
Hay, michael, patrick
Wilson, william, robert
Application Number:
JP2000613817A
Publication Date:
December 17, 2002
Filing Date:
April 26, 2000
Export Citation:
Assignee:
Cancer Research Campaign Technology Limited
International Classes:
A61K31/404; A61K31/4155; A61K31/4168; A61K31/4178; A61K31/473; A61K31/5377; A61K31/704; A61K38/44; A61K39/395; A61K48/00; A61P35/00; C07C271/20; C07C271/28; C07D209/60; C07D219/04; C07D219/08; C07D219/10; C07D231/16; C07D233/91; C07D233/92; C07D277/66; C07D307/71; C07D333/44; C07D403/14; C07D409/14; C07H15/252; (IPC1-7): C07D209/60; A61K31/404; A61K31/4155; A61K31/4168; A61K31/4178; A61K31/473; A61K31/5377; A61K31/704; A61K38/44; A61K39/395; A61K48/00; A61P35/00; C07C271/20; C07C271/28; C07D219/04; C07D219/10; C07D233/91; C07D277/66; C07D403/14; C07D409/14; C07H15/252
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)