Title:
【発明の名称】アミノ酸輸送蛋白質、アミノ酸アナログ、アッセイ装置並びにその癌の治療及び診断への使用
Document Type and Number:
Japanese Patent JPH06504031
Kind Code:
A
Abstract:
Compounds and methods for the treatment and diagnosis of cancer are provided. Also provided are methods for isolating human amino acid transporters or subunits thereof, and substantially purified transporters or subunits. In particular, there are disclosed glutamine transporters that are common to tumours, but which are generally not found, or are less active, or are present in lower quantities in most non-tumour cells. Diagnostic products and methods, and biological products relating to the amino acid transporters are disclosed. Therapeutic products including antiglutamine compounds, glutamine analogues, antibody compositions, pharmaceutical compositions and vaccines, and methods for treating animals including humans, are provided. Screening methods and apparatuses for screening compounds which inhibit glutamine uptake into tumour cells are also disclosed.
Inventors:
Palmer, Clive Frederick
MC Evoy-Bow, Edward
Mihan Giyogi, Victor
Piva, terence
Rigano, Donna
Favotte, Paula
West, Michael
Matsu Cavy, Michael Grenville Peter
Miller, David Jiyoung
MC Evoy-Bow, Edward
Mihan Giyogi, Victor
Piva, terence
Rigano, Donna
Favotte, Paula
West, Michael
Matsu Cavy, Michael Grenville Peter
Miller, David Jiyoung
Application Number:
JP51027889A
Publication Date:
May 12, 1994
Filing Date:
October 02, 1989
Export Citation:
Assignee:
Austrian Commercial Research and Development Limited
International Classes:
A61K31/195; A61K31/198; A61K31/395; A61K31/396; A61K31/397; A61K31/40; A61K31/675; A61K38/00; A61K47/48; A61K51/00; A61P7/00; A61P35/00; A61P37/00; C07C229/22; C07C229/24; C07C229/26; C07C237/04; C07C237/06; C07C237/08; C07C237/22; C07C243/34; C07C259/06; C07C275/06; C07C275/46; C07C309/66; C07C323/25; C07C323/60; C07D203/18; C07D205/08; C07D207/06; C07D207/46; C07D207/48; C07D211/42; C07D213/40; C07D213/64; C07D263/10; C07D295/14; C07D295/185; C07D295/22; C07D295/32; C07D313/00; C07F9/53; C07K1/14; C07K14/00; C07K14/005; C07K14/195; C07K14/705; C07K16/00; C07K16/30; C12P21/08; G01N33/53; G01N33/566; G01N33/574; G01N33/68; (IPC1-7): C07C229/22; A61K31/195; A61K31/395; A61K31/40; A61K31/675; A61K37/02; A61K49/02; C07C229/26; C07C237/22; C07C243/34; C07C275/06; C07C275/46; C07C323/60; C07D203/18; C07D205/08; C07D207/06; C07D207/46; C07D207/48; C07D213/40; C07D295/14; C07D295/22; C07F9/53; C07K3/02; C07K15/04; C07K15/14; C12P21/08; G01N33/53; G01N33/574
Attorney, Agent or Firm:
Yoshio Kawaguchi (4 outside)