Title:
【発明の名称】ヘム結合化合物およびその使用法
Document Type and Number:
Japanese Patent JPH08512318
Kind Code:
A
Abstract:
Inhibitors of nitric oxide formation from arginine useful for treating hypotension, inflammation, stroke and to restore vascular contractile sensitivity to the effects of alpha 1 adrenergic agonists are physiologically active compounds including N delta -substituted ornithine or N epsilon -substituted lysine moieties or monoalkyl carbon-substituted N delta -substituted ornithine or N epsilon -substituted lysine moieties, having the formula wherein R is (CH2)yCH3 or H, R' is CH2 or C(H) (CH2)yCH3, and R'' is CH2 or C(H) (CH2)yCH3, with y ranging from 0 to 5, and x is 0 or 1 and wherein none or only one of R, R' and R'' provides an alkyl substituent on ornithine or lysine moiety, and wherein Q is a heme binding moiety and/or a sulfur-containing binding moiety and Q' is -NH2 when there is a double bond between the omega carbon and Q and Q' is =NH when there is a single bond between the omega carbon and Q, and physiologically acceptable acid addition salts thereof.
Inventors:
Griffith, Owen W
Narayanan, Krishna Swami
Narayanan, Krishna Swami
Application Number:
JP50401995A
Publication Date:
December 24, 1996
Filing Date:
May 06, 1994
Export Citation:
Assignee:
The Medical College of Wisconsin Research Foundation, Incorporated
International Classes:
C07D333/20; A61K31/18; A61K31/195; A61K31/198; A61P9/00; A61P25/00; A61P37/06; A61P43/00; C07C281/16; C07C323/25; C07C335/04; C07C335/08; C07D233/64; C07D333/22; (IPC1-7): C07C281/16; A61K31/18; A61K31/195; C07C323/25; C07C335/04; C07D333/20
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)