Title:
【発明の名称】サクシンアミド誘導体と金属タンパク質分解酵素阻害剤としてのその使用
Document Type and Number:
Japanese Patent JPH11503746
Kind Code:
A
Abstract:
PCT No. PCT/GB96/00930 Sec. 371 Date Oct. 7, 1997 Sec. 102(e) Date Oct. 7, 1997 PCT Filed Apr. 18, 1996 PCT Pub. No. WO96/33161 PCT Pub. Date Oct. 24, 1996Compounds of formula (I), wherein X is a -CO2H or -CONHOH group; (I) R4 is a group -CHRxRy wherein Rx and Ry independently represent optionally substituted phenyl or monocyclic heteroaryl rings, which optionally may be linked covalently to each other by a bond or by a C1-C4 alkylene or C2-C4 alkenylene bridge; and R1, R2, R3 and R5 as defined in the specification are selective inhibitors of stromelysin-1 and matrilysin relative to human fibroblast collagenase and 72 KDa gelatinase.
Inventors:
Beckett Raymond Paul
Mirror andrew
Spavold Zo Marie
Whittaker mark
Mirror andrew
Spavold Zo Marie
Whittaker mark
Application Number:
JP53155796A
Publication Date:
March 30, 1999
Filing Date:
April 18, 1996
Export Citation:
Assignee:
British Biotech Pharmaceuticals Limited
International Classes:
A61P1/00; A61P19/10; A61P25/00; A61P27/02; A61K31/195; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07C237/22; C07C259/06; (IPC1-7): C07C237/22; A61K31/195; C07C259/06
Attorney, Agent or Firm:
Shintaro Nogawa