【発明の名称】新規な3,4-ジヒドロイソキノリン誘導体並びに炭素環式及び複素環式の縮合ジヒドロピリジンの新規な医薬としての使用

Japanese Patent JP3283877

B2

3,4-Dihydro-6,7-dimethoxy -1-(alpha-(bis(2-(2,3,4- trimethoxyphenyl)ethyl) -carbamoyl)benzyl)isoquinoline of formula (Ia) and its salts are new. Fused-ring dihydropyridine derivs. of formula (II) and their tautomers, salts and complexes are used as cerebroprotective agents, agents for treating chronic inflammatory disorders, and anticoagulants: X = OR1, NHR2 or NR3R4; R1 = H, 1-4C alkyl or 2-4C alkoxyalkyl; R2 = (a) e.g. H, 3-6C alkenyl, or (b) e.g. 1-6C alkyl opt. substd. by e.g. halogen, CN, OH, SH, 1-4C alkoxy; R3 and R4 = 1-4C alkyl opt. substd. by Ar2 or NR3R4 is a satd. or partially satd. opt. substd. 5- or 6-membered ring, opt. contg. up to two further heteroatoms (N, O and/or S): Ar1, Ar2 and R5 = phenyl opt. substd. by e.g. halogen, 1-4C alkoxy; Het = indolyl or 5- or 6-membered opt. substd. heterocyclyl contg. 1-3 heteroatoms (N, O and/or S); A = a gp. of formula A1-A4;: R5 is e.g. H, 1-4C alkyl; R6 and R7 is H, OH or R6+R7 = O(CH2)nO; R9 = H or 1-4C alkyl; R10 = H or 2-phenyl-2-ethoxycarbonylacetyl. Cpds. (I), other than (Ia), are described in EP 37934 and 251194.

Lazel Walther
Loin Otto
Arntos Dietrich
Coon Franz Joseph
Streler Ilse

JP50207392A

May 20, 2002

December 20, 1991

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Boehringer Ingelheim Commande Gesell Shaft

A61K31/4365; A61K31/437; A61K31/44; A61K31/445; A61K31/47; A61K31/472; A61K31/435; A61K31/4725; A61K31/4741; A61K31/4745; A61K31/475; A61K31/495; A61K31/496; A61K31/497; A61K31/535; A61K31/5377; A61K31/54; A61K31/541; A61P7/02; A61P9/00; A61P11/06; A61P25/00; A61P25/28; A61P29/00; C07D217/12; C07D217/18; C07D217/24; (IPC1-7): C07D217/12; A61K31/472; A61P7/02; A61P11/06; A61P25/28; A61P29/00

JP63280069A
JP56158765A
JP63258458A

Minoru Nakamura (6 outside)

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