IRAK-4:組成物および使用方法

Japanese Patent JP2004500074

A

The present invention provides nucleic acids and polypeptides for IRAK-4, a novel member of the IRAK family of protein kinases. Members of the IRAK family are indispensable signal transducer for members of the IL-1R/Toll family of transmembrane receptors, including IL-1 receptors, IL-18 receptors and LPS receptors. IRAK-4 sequences from human and mouse are provided, as are methods for identifying compounds useful in the treatment or prevention of inflammatory diseases.

WO1999019472	VECTORS COMPRISING A MAGNUM-SPECIFIC PROMOTER FOR AVIAN TRANSGENESIS
WO/1999/051755	RIBOZYME-MEDIATED CONTROL OF GENE EXPRESSION
WO/2002/059150	MATERIALS AND METHODS RELATING TO PROTEIN AGGREGATION IN NEURODEGENERATIVE DISEASE

Weske, Holger
Li, Shun

JP2001551215A

January 08, 2004

January 12, 2001

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Turalic Incorporated

A01K67/027; A61K45/00; A61P1/00; A61P1/04; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P11/14; A61P17/00; A61P17/06; A61P19/02; A61P19/06; A61P19/10; A61P25/00; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/04; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/12; C12N15/09; C12N15/12; C12N15/54; C12N15/85; C12Q1/48; A61K38/00; (IPC1-7): C12N15/09; A01K67/027; A61K45/00; A61P1/00; A61P1/04; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P11/14; A61P17/00; A61P17/06; A61P19/02; A61P19/06; A61P19/10; A61P25/00; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/04; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/12; C12Q1/48

WO1999060100A1	1999-11-25
WO1999027112A1	1999-06-03
WO1998044113A1	1998-10-08

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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