Title:
IRE*1alpha inhibitor
Document Type and Number:
Japanese Patent JP5941173
Kind Code:
B2
Abstract:
The present invention relates to compounds which directly inhibit IRE-1± activity, and which are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.
Inventors:
Paterson John Bruce
Lonar Gun David Gregory
Flynn Gary Ay.
Zen Chinpin
Paralyte buoy.
Lonar Gun David Gregory
Flynn Gary Ay.
Zen Chinpin
Paralyte buoy.
Application Number:
JP2015005455A
Publication Date:
June 29, 2016
Filing Date:
January 15, 2015
Export Citation:
Assignee:
Mankind Corporation
International Classes:
C07C47/565; A61K31/11; A61K31/145; A61K31/166; A61K31/192; A61K31/216; A61K31/343; A61K31/357; A61K31/36; A61K31/381; A61K31/41; A61K31/415; A61K31/42; A61K31/426; A61K31/427; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/4436; A61K31/4453; A61K31/47; A61K31/472; A61K31/495; A61K31/496; A61K31/505; A61K31/513; A61K31/5375; A61K31/5377; A61K45/00; A61P1/16; A61P5/14; A61P7/00; A61P7/06; A61P9/00; A61P13/12; A61P17/00; A61P19/02; A61P21/00; A61P21/04; A61P29/00; A61P31/12; A61P31/14; A61P31/20; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P43/00; C07C47/575; C07C65/30; C07C69/94; C07C205/44; C07C235/84; C07C317/24; C07D213/48; C07D213/64; C07D213/69; C07D213/74; C07D213/81; C07D215/14; C07D215/20; C07D217/16; C07D231/12; C07D239/26; C07D239/54; C07D261/08; C07D277/04; C07D277/06; C07D277/34; C07D295/12; C07D295/18; C07D307/46; C07D307/79; C07D307/80; C07D317/54; C07D319/18; C07D321/10; C07D333/20; C07D333/22; C07D333/38; C07D333/56; C07D333/58; C07D409/12; C07D417/10
Domestic Patent References:
| JP56138179A |
Other References:
Royer, Rene; Menichi, Gabriel; Buisson, Jean P.; Hubert-Habart, Michel; Cheutin, Andree; Desvoye, Marie L.,Benzofuran. XXXIV. Competition between the heterocycle and the homocycle, observed in the succinoylation of benzofurans and the cyclodehydration of various alkanoyl-substituted benzofuran derivatives,Bulletin de la Societe Chimique de France,フランス,1967年,(7),2405-13
Royer, Rene; Buisson, Jean Pierre,Studies on nitro derivatives of biological interest. Synthesis of methoxy- or halo-2-nitronaphthofurans,European Journal of Medicinal Chemistry,1980年,15(3),275-8
Royer, Rene; Buisson, Jean Pierre,Studies on nitro derivatives of biological interest. Synthesis of methoxy- or halo-2-nitronaphthofurans,European Journal of Medicinal Chemistry,1980年,15(3),275-8
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto