Title:
特異的分子の存在および過剰発現によるTR1調節リンパ球の同定法およびその応用方法
Document Type and Number:
Japanese Patent JP4546955
Kind Code:
B2
Abstract:
The invention relates to a method for identification of Tr1 lymphocyte regulators in a biological sample, based on the determination of the simultaneous presence of the molecular group CD4, CD18 and/or CD11a, CD49b and, where appropriate, by the demonstration of an over-expression of genes coding for the molecules CD4, PSGL-1, PECAM-1 and alphaV/beta3. The invention further relates to a method of quantification and a prognostic or diagnostic method for auto-immune or inflammatory diseases, based on said identification method. The invention also relates to an enrichment method for Tr1 lymphocyte regulators, based on the determination of the simultaneous presence of said molecules and, finally, an enriched composition from said enrichment method, for the treatment of an auto-immune or inflammatory disease, in particular Crohn's disease.
Inventors:
Glue Elbe
Application Number:
JP2006516319A
Publication Date:
September 22, 2010
Filing Date:
June 24, 2004
Export Citation:
Assignee:
Tee excel
International Classes:
C12N5/0783; A61K35/26; A61K39/00; A61P1/04; A61P1/16; A61P19/02; A61P29/00; A61P37/02; A61P37/06; A61P37/08; C12N15/09; C12Q1/02; C12Q1/68; G01N33/53; A61K35/12
Other References:
J.Immunol.,2003年 4月,Vol.170,No.8,p.3939-3943
Nature (Lond),1997年,Vol.389,No.6652 ,p.737-742
J.Exp.Med.,2002年,Vol.195,No.5,p.603-616
Nature (Lond),1997年,Vol.389,No.6652 ,p.737-742
J.Exp.Med.,2002年,Vol.195,No.5,p.603-616
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi