抗原エピトープの同定 - Fraunhofer Gesellschaft Tool Felderung Der Angewanten Forsung A. Fao.

Title:

抗原エピトープの同定

Document Type and Number:

Japanese Patent JP2006522319

Kind Code:

A

Abstract:

The present invention relates to methods for identifying and/or detecting T-cell epitopes of a protein antigen, to methods for preparing peptide vaccines against a protein antigen, to methods for controlling the quality of receptor/ligand complexes and/or their components, to methods for preparing nanoparticles having at least one immobilized receptor unit or an immobilized receptor, to methods for preparing nanoparticles having immobilized receptor/ligand complexes, in particular peptide-presenting MHC molecules, to methods for enriching and/or isolating specific CD4⁺-T- or CD8⁺-T-lymphocytes from peripheral blood mononuclear cells, to methods for priming a CD8⁺-T-lymphocyte reaction in vitro, to nanoparticles having an immobilized receptor unit, in particular an immobilized chain of an MHC molecule, to nanoparticles having an immobilized receptor, in particular an immobilized MHC molecule, to nanoparticles having an immobilized receptor/ligand complex, in particular a peptide-presenting MHC molecule, to a peptide vaccine, to a kit for identifying and/or detecting T-cell epitopes of a protein antigen, and to the use of the nanoparticles for identifying and/or detecting T-cell epitopes, for preparing peptide vaccines, for enriching and/or isolating specific T-lymphocytes and for priming a CD8⁺-T-lymphocyte reaction in vitro.

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Inventors:

Brunner, Helvik
Gunther, Tovar
Schiester, Thomas
Muller, Claudia Ar.
Hrad, thomas

Application Number:

JP2006504530A

Publication Date:

September 28, 2006

Filing Date:

March 03, 2004

Export Citation:

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Assignee:

Fraunhofer Gesellschaft Tool Felderung Der Angewanten Forsung A. Fao.

International Classes:

G01N33/543; A61K9/08; A61K9/10; A61K39/00; A61P37/04; B82B1/00; C07K1/02; C07K14/725; C07K14/73; C07K16/00; C07K16/18; C12N5/00; C12N15/63; C12P21/02; C12P21/06; G01N27/62; G01N33/50; G01N33/53; G01N33/552; G01N33/68; C12N15/09; C12N

Attorney, Agent or Firm:

Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Yuko Matsuniya

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