Title:
ＬＫＢ１の状態についての予測バイオマーカーとしての、遺伝子発現プロファイルの同定
Document Type and Number:
Japanese Patent JP2014524240
Kind Code:
A
Abstract:
Provided herein are methods for predicting the LKB1 status of a patient or a biological sample, comprising the measurement of particular gene expression levels relative to a set of reference levels that represent the gene expression level of a biological wild-type sample without LKB1 gene or protein loss or mutation and the gene expression level of a reference sample with LKB1 gene or protein loss or mutation. Further provided herein are methods for treating and/or preventing a cancer or a tumor syndrome in a patient, comprising administering an effective amount of a TOR kinase inhibitor to a patient having cancer or a tumor syndrome, characterized by particular gene expression levels.
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Inventors:
Nin, a you phone
シュ, Wei Min
Chopra, Rajesh
ワーランド, Peter
シュ, game シュイ
シュ, Wei Min
Chopra, Rajesh
ワーランド, Peter
シュ, game シュイ
Application Number:
JP2014524066A
Publication Date:
September 22, 2014
Filing Date:
August 02, 2012
Export Citation:
Assignee:
Signal Fame shoe tee カルズ, LLC
International Classes:
C12Q1/68; A61K45/00; A61P35/00; A61P35/02; C12M1/00; C12M1/34; C12N15/09; C12Q1/04; C12Q1/48; G01N33/68
Domestic Patent References:
| JP2001017171A | 2001-01-23 | |||
| JP2007530006A | 2007-11-01 |
Foreign References:
| WO2011066200A1 | 2011-06-03 | |||
| EP1772521A1 | 2007-04-11 | |||
| WO2009137921A1 | 2009-11-19 |
Other References:
JPN6016022466; Ｐｒｏｃｅｅｄｉｎｇｓ ｏｆ ｔｈｅ Ｎａｔｉｏｎａｌ Ａｃａｄｅｍｙ ｏｆ Ｓｃｉｅｎｃｅｓ Ｖｏｌ．１０７， Ｎｏ．４４, 2010, ｐ．１８８９２-１８８９７
JPN6016022467; Ｃａｎｃｅｒ Ｃｅｌｌ Ｖｏｌ．１７， Ｎｏ．６, 2010, ｐ．５４７-５５９
JPN6016022468; Ｊｏｕｒｎａｌ ｏｆ Ｈｅｍａｔｏｌｏｇｙ ＆ Ｏｎｃｏｌｏｇｙ Ｖｏｌ．２， Ｎｏ．１, 2009, ｐ．４５（全１２頁）
JPN6016022467; Ｃａｎｃｅｒ Ｃｅｌｌ Ｖｏｌ．１７， Ｎｏ．６, 2010, ｐ．５４７-５５９
JPN6016022468; Ｊｏｕｒｎａｌ ｏｆ Ｈｅｍａｔｏｌｏｇｙ ＆ Ｏｎｃｏｌｏｇｙ Ｖｏｌ．２， Ｎｏ．１, 2009, ｐ．４５（全１２頁）
Attorney, Agent or Firm:
Patent business corporation HARAKENZO WORLD PATENT & TRADEMARK