Title:
IgG4 stable antibody
Document Type and Number:
Japanese Patent JP6034315
Kind Code:
B2
Abstract:
The present invention relates to stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position 409, the Phe residue at position 405 or the Lys residue at position 370.
Inventors:
Bande Winkel Yang
Bink Tom
Sulferman Jenin
Parlen Paul
Arl bel celob
Van der Nout Corfus Skoten Malein
Bink Tom
Sulferman Jenin
Parlen Paul
Arl bel celob
Van der Nout Corfus Skoten Malein
Application Number:
JP2014016803A
Publication Date:
November 30, 2016
Filing Date:
January 31, 2014
Export Citation:
Assignee:
GENMAB A/S
International Classes:
C07K16/00; A61K39/395; C12P21/08
Foreign References:
| WO2006106905A1 | ||||
| WO2006033386A1 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto