Title:
イメージングリガンド
Document Type and Number:
Japanese Patent JP2012509887
Kind Code:
A
Abstract:
Naphthoxazine derivatives which are selective ligands for the dopamine D2 receptor and which carry an 18F radio-label suitable for imaging with PET are described. The compounds of the present invention are thus useful for in vivo diagnostics and in vivo imaging of the dopamine D2 receptor.
Inventors:
Hedge, ravi
Atreya, Chandan
Shan, Bo
Adak, Sudeshna
Atreya, Chandan
Shan, Bo
Adak, Sudeshna
Application Number:
JP2011537640A
Publication Date:
April 26, 2012
Filing Date:
November 20, 2009
Export Citation:
Assignee:
GENERAL ELECTRIC COMPANY
International Classes:
C07D265/34; A61K49/00; G01T1/161
Domestic Patent References:
| JPH05508408A | 1993-11-25 | |||
| JPS5892670A | 1983-06-02 |
Foreign References:
| WO2006084368A1 | 2006-08-17 | |||
| WO2006047861A1 | 2006-05-11 | |||
| US4540691A | 1985-09-10 | |||
| WO1993024471A1 | 1993-12-09 |
Other References:
JPN5012004311; ＶＡＳＤＥＶ: 'ＳＹＮＴＨＥＳＥＳ ＡＮＤ ＩＮ ＶＩＴＲＯ ＥＶＡＬＵＡＴＩＯＮ ＯＦ ＦＬＵＯＲＩＮＡＴＥＤ ＮＡＰＨＴＨＯＸＡＺＩＮＥＳ ＡＳ ＤＯＰＡＭＩＮＥ Ｄ２／Ｄ３ 以下備考' ＮＵＣＬＥＡＲ ＭＥＤＩＣＩＮＥ ＡＮＤ ＢＩＯＬＯＧＹ Ｖ３４ Ｎ２, 20070215, Ｐ１９５-２０３, ＥＬＳＥＶＩＥＲ
Attorney, Agent or Firm:
Arakawa Satoshi
Hirokazu Ogura
Toshihisa Kurokawa
Hirokazu Ogura
Toshihisa Kurokawa