Title:
イミダゾリジン誘導体、その製造方法、その使用およびそれを含有する製剤
Document Type and Number:
Japanese Patent JP4567881
Kind Code:
B2
Abstract:
The present invention relates to imidazolidine derivatives of the formula I,in which B, E, W, Y, R, R<2>, R<3>, R<30>, e and h have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds, which are suitable, for example, for the therapy and prophylaxis of inflammatory disorders, for example of rheumatoid arthritis, or of allergic disorders. The compounds of the formula I are inhibitors of the adhesion and migration of leukocytes and/or antagonists of the adhesion receptor VLA-4 belonging to the integrins group. They are generally suitable for the therapy or prophylaxis of diseases which are caused by an undesired extent of leukocyte adhesion and/or leukocyte migration or are associated therewith, or in which cell-cell or cell-matrix interactions which are based on interactions of VLA-4 receptors with their ligands play a part. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use, in particular as pharmaceutical active compounds, and pharmaceutical preparations which contain compounds of the formula I.
Inventors:
Bernhard Niizez
Volkmar Weener
Hans Ulrich Stilts
Volkmar Weener
Hans Ulrich Stilts
Application Number:
JP2000549633A
Publication Date:
October 20, 2010
Filing Date:
May 05, 1999
Export Citation:
Assignee:
Sanofi-Aventis Deutschland Gesellschaft Mitt Beschlenktel Haftung
International Classes:
C07D233/72; C07D233/74; A61K31/4166; A61K31/4178; A61P1/04; A61P3/10; A61P9/00; A61P9/10; A61P11/06; A61P19/02; A61P25/00; A61P29/00; A61P29/02; A61P33/06; A61P35/00; A61P35/04; A61P37/06; A61P37/08; A61P43/00; C07D233/76; C07D405/12; C07K5/02; A61K38/00
Domestic Patent References:
| JP10158298A | ||||
| JP9505062A | ||||
| JP4217962A | ||||
| JP5213895A | ||||
| JP7053590A |
Attorney, Agent or Firm:
Junji Yuda
Chika Takagi
Kosuke Nishimura
Chika Takagi
Kosuke Nishimura