Title:
イミダゾピラジンSyk阻害剤
Document Type and Number:
Japanese Patent JP5567587
Kind Code:
B2
Abstract:
Certain imidazopyrazines and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.
Inventors:
Mitchell, Scott A.
Curry, Kevin S.
Brom Glen, Peter A.
Croff, Jeffrey E.
Lee, Sun H.
Xu, Jiang Jun
Stafford, Douglas G.
Harding, James P.
Barbosa, Antonio Jay. Jr.
Chao, Jeongdong
Armystead, David M.
Curry, Kevin S.
Brom Glen, Peter A.
Croff, Jeffrey E.
Lee, Sun H.
Xu, Jiang Jun
Stafford, Douglas G.
Harding, James P.
Barbosa, Antonio Jay. Jr.
Chao, Jeongdong
Armystead, David M.
Application Number:
JP2011539524A
Publication Date:
August 06, 2014
Filing Date:
December 07, 2009
Export Citation:
Assignee:
Gilead Connecticut, Incorporated
International Classes:
C07D487/04; A61K31/5377; A61P11/00; A61P11/02; A61P11/08; A61P13/12; A61P19/02; A61P29/00; A61P35/00; A61P35/02; A61P37/06; A61P37/08; A61P43/00; A61K31/4985; A61K31/506; A61K31/538; A61K31/5383; A61K31/553; C07D471/04; C07D519/00
Domestic Patent References:
| JP2004528295A | ||||
| JP2008519843A | ||||
| JP2001302667A |
Foreign References:
| WO2005047290A1 | ||||
| WO2005085252A1 | ||||
| US20060183746 | ||||
| WO2010068258A1 | ||||
| WO2009102468A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita