IMIDODISULFAMIDE DERIVATIVE, ITS MANUFACTURE AND MEDICINAL COMPOSITION CONTAINING IT

Title:

IMIDODISULFAMIDE DERIVATIVE, ITS MANUFACTURE AND MEDICINAL COMPOSITION CONTAINING IT

Document Type and Number:

Japanese Patent JPS56131560

Kind Code:

A

Abstract:

Compounds of formula (1):- and pharmaceutically acceptable salts thereof are disclosed with a process for their preparation. In formula (I) A is a covalent bond, an alkylene chain -(CH2)n- in which n is a positive integer 2,3,4 or 6, a branched alkylene chain of from 2 to 4 carbon atoms, or phenylmethylene; R1 is hydrogen, 3- or 4-bromo, 3- or 4-chloro or 3- or 4-trifluoromethyl; and R2 is hydrogen, with the proviso that when n is 2, R1 is 4-chloro, 4-bromo, 4-methoxy or 3-trifluoromethyl and R2 is hydrogen or together with R1 in adjacent positions forms either a 3,4-dichloro substitution or a fused benzo ring, and further with the proviso that when A is a covalent bond R1 is not hydrogen or 4-chloro. The compounds of the invention are SRS-A antagonists.

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Inventors:

FUADEIA ERUFUEHAIRU ARI
ROBAATO DONARUDO KURERU
KENESU MIINZU SUNEIDAA

Application Number:

JP2000781A

Publication Date:

October 15, 1981

Filing Date:

February 12, 1981

Export Citation:

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Assignee:

SMITHKLINE CORP

International Classes:

C07C307/06; A61K31/095; A61K31/16; A61P11/00; A61P37/08; C07C67/00; C07C301/00; C07C303/38; C07C307/02; C07C307/10; (IPC1-7): A61K31/16; C07C143/86

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