二重ｓｈＲＮＡを用いて強化された免疫細胞及びそれを含む組成物

Title:

二重ｓｈＲＮＡを用いて強化された免疫細胞及びそれを含む組成物

Document Type and Number:

Japanese Patent JP7394914

Kind Code:

B2

Abstract:

The present invention relates to a vector comprising: a) a base sequence encoding two types of short hairpin RNA (shRNA), which inhibit the expression of at least one gene that weakens the function of immune cells, and b) a nucleotide sequence encoding a chimeric antigen receptor (CAR), wherein the CAR comprises an extracellular antigen recognition domain, a transmembrane domain, and an intracellular signal transduction domain.

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Inventors:

Chang Hyuk Kim
Young-Holly
Eugene Lee
Hieon Guji Lee
Sang Ho Only

Application Number:

JP2022074779A

Publication Date:

December 08, 2023

Filing Date:

April 28, 2022

Export Citation:

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Assignee:

Crocell ink.
Korea Advanced Institute of Science and Technology

International Classes:

C12N15/63; A61K35/12; A61K35/17; A61P35/00; C12N5/0783; C12N5/10; C12N15/113; C12N15/12; C12N15/13; C12N15/62

Domestic Patent References:

JP2017500869A
JP2017513818A
JP2016526883A

Foreign References:

WO2017040945A1
WO2017158019A1
CN106967681A
US20080293142

Attorney, Agent or Firm:

Toru Ishikawa

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