Title:
免疫抑制を逆転させるための免疫治療
Document Type and Number:
Japanese Patent JP2005510491
Kind Code:
A
Abstract:
A method for overcoming immune suppression includes the steps of inducing production of naïve T cells and restoring T cell immunity. A method of vaccine immunotherapy includes the steps of inducing production of naïve T cells and exposing the naïve T cells to endogenous or exogenous antigens at an appropriate site. Additionally, a method for unblocking immunization at a regional lymph node includes the steps of promoting differentiation and maturation of immature dendritic cells at a regional lymph node and allowing presentation of processed peptides by resulting mature dendritic cells, thus, for example, exposing tumor peptides to T cells to gain immunization of the T cells. Further, a method of treating cancer and other persistent lesions includes the steps of administering an effective amount of a natural cytokine mixture as an adjuvant to endogenous or exogenous administered antigen to the cancer or other persistent lesions; preferably the natural cytokine mixture is administered in combination with thymosin.
Inventors:
Hayden, John W..
Application Number:
JP2003537573A
Publication Date:
April 21, 2005
Filing Date:
October 26, 2002
Export Citation:
Assignee:
Immuno-Rx, Inc.
International Classes:
A61K38/00; A61K31/405; A61K31/415; A61K31/4402; A61K31/664; A61K38/19; A61K38/21; A61K38/22; A61K39/00; A61K39/39; A61P31/04; A61P35/00; A61P37/04; A61P43/00; C12N5/08; (IPC1-7): A61K38/00; A61K31/405; A61K31/415; A61K31/4402; A61K31/664; A61K38/21; A61K39/00; A61K39/39; A61P31/04; A61P35/00; A61P37/04; A61P43/00
Domestic Patent References:
| JPH10509955A | 1998-09-29 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita