Title:
免疫学的に重要な単純ヘルペスウイルス抗原およびそれを用いる方法
Document Type and Number:
Japanese Patent JP4519461
Kind Code:
B2
Abstract:
A pharmaceutical composition comprising (1) a polypeptide which is (a) a fragment of the herpes simplex virus (HSV) protein U L 49 comprising amino acids 49-57 of, respectively, HSV-2 or HSV-1:
Arg Pro Arg Gly Glu Val Arg Phe Leu (SEQ ID NO: 1) or
Arg Gln Arg Gly Glu Val Arg Phe Val (SEQ ID NO: 2)
and having a length of less than 50 amino acids, or a variant of such a fragment, having a length of less than 50 amino acids and exhibiting at least 70% identity therewith, and which elicits a cellular immune response to HSV-2 or HSV-1, respectively, (b) a fusion protein comprising at least one above-defined fragment or variant and an unrelated sequence or comprising multiple above-defined fragments or variants and (2) a pharmaceutically acceptable carrier.
Inventors:
Coerry David M.
Hosken Nancy Ann
Posabad Christine M.
Chen Hongbo
McGowan Patrick
Hosken Nancy Ann
Posabad Christine M.
Chen Hongbo
McGowan Patrick
Application Number:
JP2003517084A
Publication Date:
August 04, 2010
Filing Date:
July 31, 2002
Export Citation:
Assignee:
University of Washington
Corixa Corporation
Fred Hutchinson Cancer Research Center
Corixa Corporation
Fred Hutchinson Cancer Research Center
International Classes:
C12N15/09; A61K31/7088; A61K35/76; A61K38/00; A61K39/245; A61P31/22; C07K14/03; C07K14/035; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/00; C12P21/02; A61K39/00
Foreign References:
| WO2001023414A1 | ||||
| WO2000008051A1 |
Other References:
J. Immunol.,2001年 3月15日,Vol.166,pp.4049-4058
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi