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Patent Searching and Data


Title:
IMMUNOMODULATING POLYMER
Document Type and Number:
Japanese Patent JP2011121986
Kind Code:
A
Abstract:

To provide methods and products for inducing IL-2 secretion, inducing IL-10 secretion, activating T cells, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing adhesion formation after surgical operation, and protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation.

The method includes locally administrating a polymer having at least two repeating charge motifs separated by at least a certain minimum distance, preferably a zwitterionic non-polysaccharide polymer. The repeating charge motif includes a positively charged free amino moiety and a negative charge, and the positively charged free amino moieties of at least two repeating charge motifs are preferably separated by a distance of at least 32 .


Inventors:
TZIANABOS ARTHUR O
KASPER DENNIS L
ONDERDONK ANDREW B
WANG YING
Application Number:
JP2011032678A
Publication Date:
June 23, 2011
Filing Date:
February 17, 2011
Export Citation:
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Assignee:
BRIGHAM & WOMENS HOSPITAL INC
International Classes:
A61K31/715; A61K31/192; A61K31/7088; A61K31/785; A61K35/26; A61K35/74; A61K38/00; A61K38/16; A61K38/20; A61K39/395; A61K45/00; A61K45/06; A61P1/04; A61P3/10; A61P29/00; A61P31/18; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P41/00; A61P43/00; C12N5/07; C12N5/0783
Attorney, Agent or Firm:
Kiyoji Kuzuwa