Title:
免疫調節ポリペプチドならびに関連する組成物および方法
Document Type and Number:
Japanese Patent JP7295795
Kind Code:
B2
Abstract:
Provided herein are immunomodulatory polypeptides containing first and second submits of a cytokine or a chemokine connected by a joining region containing a targeting moiety that binds to a target molecule. In some aspects, the disclosure further relates to engineered cells and compositions comprising the immunomodulatory polypeptides and methods for their administration to subjects. In some embodiments, the cells engineered to contain the immunomodulatory polypeptide, such as T cells, further contain a genetically engineered antigen receptor that specifically binds to antigens, such as a chimeric antigen receptor (CAR). In some embodiments, features of the polypeptides, engineered cells, and methods provide for improved treatment of diseases or disorders, such as by reducing adverse effects of cytokine or chemokine therapy, or increasing activity, efficacy and/or persistence or decreasing immunogenicity of adoptive cell therapy.
Inventors:
hosekins colin
Evens Allen
Evens Allen
Application Number:
JP2019504812A
Publication Date:
June 21, 2023
Filing Date:
July 28, 2017
Export Citation:
Assignee:
Juneau Therapeutics Incorporated
International Classes:
C12N15/62; A61K35/12; A61K35/17; A61K38/20; A61K47/42; A61P31/00; A61P35/00; A61P37/02; C07K7/00; C07K14/435; C07K14/51; C07K14/54; C07K14/78; C07K19/00; C12N5/10; C12N15/12; C12N15/24; C12N15/63
Domestic Patent References:
| JP2003507012A |
Other References:
J. Immunol.,1999年,Vol. 162,pp.1064-1070
Cancer Res.,2011年,Vol. 71, Issue 17,pp.5697-5706
Cancer Res.,2011年,Vol. 71, Issue 17,pp.5697-5706
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto