Title:
免疫調節組成物
Document Type and Number:
Japanese Patent JP5289706
Kind Code:
B2
Abstract:
Isolated immunomodulatory (e.g. immunostimulatory) polyhydroxlated pyrrolizidine compounds having the formula (I), wherein R is selected from the group comprising hydrogen, straight or branched, unsubstituted or substituted, saturated or unsaturated acyl, alkyl (e.g. cycloalkyl), alkenyl, alkynyl and aryl groups, or a pharmaceutically acceptable salt or derivative thereof, are useful in therapy and prophylaxis, including increasing the Th1:Th2 response ratio, haemorestoration, alleviation of immuno-suppression, cytokine stimulation, treatment of proliferative disorders (e.g. cancer), vaccination, stimulation of the innate immune response and boosting of the activity of endogenous NK cells.
Inventors:
Allison, Ann, Watson
Robert, James, Nash
Emma, Luisa, Evvinson
Robert, James, Nash
Emma, Luisa, Evvinson
Application Number:
JP2006500223A
Publication Date:
September 11, 2013
Filing Date:
January 21, 2004
Export Citation:
Assignee:
M N L PHARMA LIMITED
International Classes:
A61K31/407; A61K31/40; A61K31/7028; A61K31/7056; A61K36/185; A61K36/61; A61K45/06; A61P31/00; A61P31/04; A61P31/12; A61P35/00; A61P37/02; A61P43/00; C07D487/04; C07H3/02; C07H17/02
Domestic Patent References:
| JP2000072770A |
Other References:
Andrew A. Bell et al.,Synthesis of Casuarines [Pentahydroxylated Pyrrolizidines] by Sodium Hydrogen Telluride-Induced Cyclisations of Azidodimesylates,Tetrahedron Letters,1997年,Vol.38, No.33,p.5869-5872
WORMALD M. R. et al.,CARBOHYDRATE LETTERS,1996年,Vol.2, No.3,p.169-174
Scott E. Denmark et al.,Organic Letters,1999年,Vol.1, No.8,p.1311-1314
WORMALD M. R. et al.,CARBOHYDRATE LETTERS,1996年,Vol.2, No.3,p.169-174
Scott E. Denmark et al.,Organic Letters,1999年,Vol.1, No.8,p.1311-1314
Attorney, Agent or Firm:
Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Yukitaka Nakamura
Konno Akio
Noritaka Yokota