Title:
トール様受容体に基づく免疫反応を調節するための免疫調節オリゴヌクレオチド（ＩＲＯ）化合物
Document Type and Number:
Japanese Patent JP5813778
Kind Code:
B2
Abstract:
The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
Inventors:
Ekanber Earl Candimara
Dachin Wan
Ireneush Novak
Sudir Agrawal
Dachin Wan
Ireneush Novak
Sudir Agrawal
Application Number:
JP2013540054A
Publication Date:
November 17, 2015
Filing Date:
November 18, 2011
Export Citation:
Assignee:
Idera Pharmaceuticals, Inc.
International Classes:
C12N15/117; A61K31/7115; A61K31/712; A61K45/00; A61K48/00; A61P1/00; A61P1/16; A61P7/04; A61P7/06; A61P11/00; A61P13/00; A61P13/10; A61P17/00; A61P17/06; A61P19/02; A61P25/18; A61P29/00; A61P37/02; A61P43/00
Foreign References:
| WO2009154609A1 |
Other References:
J.Med.Chem., 2009, Vol. 52, No. 16, pp. 5108-5114
Bioorg.Med.Chem., 2001, Vol. 9, No. 3, pp. 807-813
J.Med.Chem., 2009, Vol. 52, No. 2, pp. 551-558
Bioorg.Med.Chem., 2001, Vol. 9, No. 3, pp. 807-813
J.Med.Chem., 2009, Vol. 52, No. 2, pp. 551-558
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Masahiro Nitta
Kure Hidenori
Nobuhiko Akiyama
Samejima Mutsumi
Masahiro Nitta
Kure Hidenori
Nobuhiko Akiyama