Title:
シリル化治療剤を結合したインプラント
Document Type and Number:
Japanese Patent JP2007505697
Kind Code:
A
Abstract:
The present invention is directed to implants that include therapeutic molecules bonded to their surfaces. The therapeutic molecules interact with cells that are adjacent, near, or adhering to the implant. The covalently-bonded therapeutic molecules may be released from the implant surface by changes in pH or enzymes characteristic of cells adjacent to the implant. Preferably the covalently-bonded agents include an antibiotics that are released from the implant surface by bacteria and in this way ensures that the antibiotic is released at sites on the implant that would serve as centers for both bacterial colonization and biofilm formation.
Inventors:
WICKSTROM,Eric
HICKOK,Noreen J.
PARVIZI,Javad
HICKOK,Noreen J.
PARVIZI,Javad
Application Number:
JP2006526981A
Publication Date:
March 15, 2007
Filing Date:
September 14, 2004
Export Citation:
Assignee:
WICKSTROM,Eric
HICKOK,Noreen J.
PARVIZI,Javad
HICKOK,Noreen J.
PARVIZI,Javad
International Classes:
A61L27/00; A61B17/58; A61K31/496; A61K31/65; A61K31/7036; A61K31/711; A61K38/00; A61K45/00; A61K47/16; A61K47/24; A61K47/34; A61K47/48; A61K48/00; A61L27/28; A61L27/34; A61L27/50; A61L27/54; A61P7/02; A61P9/14; A61P19/00; A61P19/02; A61P19/08; A61P29/00; A61P31/00; A61P31/04; A61P35/00; A61P41/00; A61P43/00; A61F2/00; A61F2/28
Foreign References:
| WO1999026674A2 | 1999-06-03 |
Other References:
JPN6011006218; Ｌａｎｇｍｕｉｒ Ｖｏｌ．１５，Ｎｏ．２０, 1999, ｐ６９３１-６９３９
JPN6011000501; Ｂｉｏｍａｃｒｏｍｏｌｅｃｕｌｅｓ Ｖｏｌ．３，Ｎｏ．６, 2002, ｐ１２８６-１２９５
JPN6011000499; Ｊｏｕｒｎａｌ ｏｆ Ｂｉｏｍｅｄｉｃａｌ Ｍａｔｅｒｉａｌｓ Ｒｅｓｅａｒｃｈ． Ｐａｒｔ Ａ． Ｖｏｌ．６５，Ｎｏ．４, 2003, ｐ４９８-５１０
JPN6011006220; Ｂｉｏｃｏｎｊｕｇａｔｅ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１３，Ｎｏ．４, 2002, ｐ７９２-８０３
JPN6011006221; Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ｐ２５１７-２５２４, 1999
JPN6011006222; Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｖｏｌ．１３，Ｎｏ．３, 200302, ｐ３５５-３６０
JPN6011006223; Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ Ｖｏｌ．８７，Ｎｏ．３, 1998, ｐ３３８-３４６
JPN6011006224; Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．８，Ｎｏ．８, 2000, ｐ２１７５-２１８４
JPN6011006225; Ｊｏｕｒｎａｌ ｏｆ Ｃｏｎｔｒｏｌｌｅｄ Ｒｅｌｅａｓｅ Ｖｏｌ．６９，Ｎｏ．１, 2000, ｐ２７-４１
JPN6011006227; Ｊｏｕｒｎａｌ ｏｆ Ｃｏｎｔｒｏｌｌｅｄ Ｒｅｌｅａｓｅ Ｖｏｌ．７９，Ｎｏ．１-３, 2002, ｐ２９９-２４２
JPN6011000501; Ｂｉｏｍａｃｒｏｍｏｌｅｃｕｌｅｓ Ｖｏｌ．３，Ｎｏ．６, 2002, ｐ１２８６-１２９５
JPN6011000499; Ｊｏｕｒｎａｌ ｏｆ Ｂｉｏｍｅｄｉｃａｌ Ｍａｔｅｒｉａｌｓ Ｒｅｓｅａｒｃｈ． Ｐａｒｔ Ａ． Ｖｏｌ．６５，Ｎｏ．４, 2003, ｐ４９８-５１０
JPN6011006220; Ｂｉｏｃｏｎｊｕｇａｔｅ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１３，Ｎｏ．４, 2002, ｐ７９２-８０３
JPN6011006221; Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ｐ２５１７-２５２４, 1999
JPN6011006222; Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｖｏｌ．１３，Ｎｏ．３, 200302, ｐ３５５-３６０
JPN6011006223; Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ Ｖｏｌ．８７，Ｎｏ．３, 1998, ｐ３３８-３４６
JPN6011006224; Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．８，Ｎｏ．８, 2000, ｐ２１７５-２１８４
JPN6011006225; Ｊｏｕｒｎａｌ ｏｆ Ｃｏｎｔｒｏｌｌｅｄ Ｒｅｌｅａｓｅ Ｖｏｌ．６９，Ｎｏ．１, 2000, ｐ２７-４１
JPN6011006227; Ｊｏｕｒｎａｌ ｏｆ Ｃｏｎｔｒｏｌｌｅｄ Ｒｅｌｅａｓｅ Ｖｏｌ．７９，Ｎｏ．１-３, 2002, ｐ２９９-２４２
Attorney, Agent or Firm:
Hironobu Onda
Makoto Onda
Makoto Onda