Title:
糖尿病及びスティフマン症候群の診断及び治療用改良試薬及び方法
Document Type and Number:
Japanese Patent JP4242446
Kind Code:
B2
Abstract:
The invention provides fragments of GAD65 that are specifically reactive with at least one class of GAD65 autoantibody. Most fragments are substantially free of N-terminal amino acids that would otherwise limit solubility. Different fragment contain epitopes for different classes of GAD65 autoantibodies. The fragments are used in methods of diagnosing and treating insulin dependent diabetes mellitus and stiff man syndrome.
Inventors:
Birkeskov Steinan
Richter Wirthroot
Namchuk mark
Xiuguan
Kim john
Richter Wirthroot
Namchuk mark
Xiuguan
Kim john
Application Number:
JP51349794A
Publication Date:
March 25, 2009
Filing Date:
December 02, 1993
Export Citation:
Assignee:
The Regents of The University of California
International Classes:
G01N33/564; A61K38/00; A61K39/395; A61P3/08; A61P3/10; A61P37/00; A61P43/00; C07K7/06; C07K7/08; C07K14/47; C07K16/40; C07K19/00; C12N9/88; C12N15/09; C12P21/00; G01N33/573; G01N33/68; G01N33/74; C12R1/91
Foreign References:
| WO1992005446A1 |
Other References:
J. Cell Biol.,1992年 7月,Vol.118, No.2,pp.309-320
Proc. Natl. Acad. Sci. USA,1991年,Vol.88,pp.8337-8341
Proc. Natl. Acad. Sci. USA,1992年 3月,Vol.89,pp.2115-2119
Proc. Natl. Acad. Sci. USA,1991年,Vol.88,pp.8337-8341
Proc. Natl. Acad. Sci. USA,1992年 3月,Vol.89,pp.2115-2119
Attorney, Agent or Firm:
Minoru Nakamura
Fumiaki Otsuka
Shishido Kaichi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Fumiaki Otsuka
Shishido Kaichi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo