Title:
改良型抗ＶＥＧＦＲ−２モノクローナル抗体
Document Type and Number:
Japanese Patent JP6843262
Kind Code:
B2
Abstract:
The application belongs to the technical field of biomedicines and provides an improved anti-Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) monoclonal antibody and an application thereof. By a computer-aided simulation design, a novel phage antibody library is designed, and an improved anti-VEGFR-2 monoclonal antibody is obtained after multiple rounds of screening. Both affinity and biological activity of the antibody are higher than those of an original antibody. The antibody is capable of effectively inhibiting combination of VEGFR-2 and a ligand Vascular Endothelial Growth Factor (VEGF) thereof in vitro, and may be used in treating a tumor and a disease caused by angiogenesis such as macular degeneration.
Inventors:
White
Kaori Tani
Kaori Tani
Application Number:
JP2019546906A
Publication Date:
March 17, 2021
Filing Date:
February 14, 2018
Export Citation:
Assignee:
BEIJING DONGFANG BIOTECH CO.LTD.
International Classes:
C12N15/13; A61K39/395; A61K47/68; A61P27/02; A61P35/00; C07K16/28; C12N1/19; C12N1/21; C12N5/10; C12N15/63; C12N15/81; C12N15/85; C12P21/08; G01N33/53; G01N33/573
Foreign References:
| CN103333247A | ||||
| WO2003075840A1 |
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe