Title:
ベンズヒドリルチオアセトアミドの改良製法
Document Type and Number:
Japanese Patent JP2006518754
Kind Code:
A
Abstract:
The present invention is directed to an improved process for preparing modafinil wherein benzhydrylthioacetamide is prepared in high yield and purity by the reaction of a haloacetamide with the reaction product of thiourea and benzhydrol in aqueous solution. The reaction employing the haloacetamide is conducted in a solvent comprising water and an organic solvent such as dimethylformamide having dissolved therein a basic salt such as potassium carbonate. The resulting benzhydrylthioacetamide can be oxidized to provide the pharmaceutical modafinil.
More Like This:
| WO/1995/013700 | USE OF COPPER (II) METHIONINATE AS FUNGICIDE IN VITICULTURE |
| WO/1992/003412 | BENZAMIDE DERIVATIVES |
Inventors:
Sidney Lian
Application Number:
JP2006503792A
Publication Date:
August 17, 2006
Filing Date:
February 23, 2004
Export Citation:
Assignee:
Mallinckrodt INC.
International Classes:
C07C319/20; C07C315/02; C07C315/06; C07C317/44; C07C319/14; C07C323/60; C07C335/32
Domestic Patent References:
| JP2004509080A | 2004-03-25 | |||
| JPS53121724A | 1978-10-24 |
Foreign References:
| EP1260501A1 | 2002-11-27 |
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Mitsutaka Iwasaki
Shoji Nakajima