Title:
IMPROVED METHODS OF CELL CULTURE FOR ADOPTIVE CELL THERAPY
Document Type and Number:
Japanese Patent JP2018138059
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To produce therapeutic cells that can be used independent of whether or not there is an HLA match between a donor and a recipient.SOLUTION: A method comprises: stimulating donor PBMCs or donor cord blood with an antigen in order to activate the growth of T cells that have native antigen specificity to the antigen, so as to produce an antigen-specific T cell population that comprises native antigen receptors that have antigen specificity to the antigen. Then, the antigen-specific T cell population is altered to include therapeutic attributes independent of the antigen specificity of the native antigen receptors.SELECTED DRAWING: Figure 14
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Inventors:
WILSON JOHN R
Application Number:
JP2018114352A
Publication Date:
September 06, 2018
Filing Date:
June 15, 2018
Export Citation:
Assignee:
WOLF WILSON MFG CORP
International Classes:
C12N5/0783; A61K35/51; A61K39/00
Domestic Patent References:
| JP2015519080A | 2015-07-09 | |||
| JP2009213462A | 2009-09-24 |
Foreign References:
| WO2012138858A1 | 2012-10-11 |
Other References:
NAKAZAWA Y. ET AL., MOLECULAR THERAPY, vol. 19(12)(2011), JPN6017009780, pages 2133 - 2143, ISSN: 0004250216
VERA J.F. ET AL., BLOOD, vol. 112(11)(2008), JPN6017009783, pages 3534, ISSN: 0004250217
CURRAN K. J. ET AL., MOLECULAR THERAPY, vol. Vol.19 Suppl 1 (2011), JPN6019016527, pages 90, ISSN: 0004250218
TERAKURA S. ET AL., BLOOD, vol. Vol.119, No.1 (2012), JPN6019016529, pages 72 - 82, ISSN: 0004250219
ZOHREN F. ET AL., BLOOD, vol. 118(21)(2011), JPN6017009784, pages 644, ISSN: 0004250220
VALLERA D.A., CANCER RES., vol. 60(2000), JPN6017009781, pages 976 - 984, ISSN: 0004250221
大沢 利昭 他, 免疫学辞典, vol. 第２版, JPN6018005080, 2001, pages 634, ISSN: 0004029992
VERA J.F. ET AL., BLOOD, vol. 112(11)(2008), JPN6017009783, pages 3534, ISSN: 0004250217
CURRAN K. J. ET AL., MOLECULAR THERAPY, vol. Vol.19 Suppl 1 (2011), JPN6019016527, pages 90, ISSN: 0004250218
TERAKURA S. ET AL., BLOOD, vol. Vol.119, No.1 (2012), JPN6019016529, pages 72 - 82, ISSN: 0004250219
ZOHREN F. ET AL., BLOOD, vol. 118(21)(2011), JPN6017009784, pages 644, ISSN: 0004250220
VALLERA D.A., CANCER RES., vol. 60(2000), JPN6017009781, pages 976 - 984, ISSN: 0004250221
大沢 利昭 他, 免疫学辞典, vol. 第２版, JPN6018005080, 2001, pages 634, ISSN: 0004029992
Attorney, Agent or Firm:
Okada International Patent Office