Title:
（Ｅ）−（５，６−ジヒドロ−１，４，２−ジオキサジン−３−イル）（２−ヒドロキシフェニル）メタノンＯ−メチルオキシムを調製する改善されたプロセス
Document Type and Number:
Japanese Patent JP6930923
Kind Code:
B2
Abstract:
A process for preparing (E)-(5,6-dihydro-l,4,2-dioxazin-3-yl)(2- hydroxyphenyl)methanone O-methyl oxime is described which includes: (i) reacting benzofuran-3(2H)-one O-methyl oxime (1) with at least one nitrite selected from n-butyl nitrite and tert-butyl nitrite, in the presence of a metal alkoxide to form (2Z,32)-2,3-benzofuran-dione O3-methyl dioxime (2) as the predominant isomer; (ii) reacting the (2Z,3Z)-2,3-benzofuran-dione O -methyl dioxime (2) with 2- haloethanol to form (2Z,3Z)-benzofuran-2,3-dione 02-(2-hydroxyethyl) O3 -methyl dioxime (3); and (iii) reacting the (2Z,3Z)-benzofuran-2,3-dione 02-(2-hydroxyethyl) & -methyl dioxime (3) with an acid to form (E)-(5,6-dihydro-l,4,2-dioxazin-3-yl)(2- hydroxyphenyl)methanone (9-methyl oxime (4);
Inventors:
Vic Prasad
Cameron Gibb
Christopher Lynn Larson
Acai Surikans
Jivan Dun Large Power
Sankar Balakrishnan
K.N.Lavikumar
Avinash Chessaro Maine
Saji Satish
San Padalao Ananda Lao
Cameron Gibb
Christopher Lynn Larson
Acai Surikans
Jivan Dun Large Power
Sankar Balakrishnan
K.N.Lavikumar
Avinash Chessaro Maine
Saji Satish
San Padalao Ananda Lao
Application Number:
JP2017561838A
Publication Date:
September 01, 2021
Filing Date:
May 10, 2016
Export Citation:
Assignee:
Arista Life Science Co., Ltd.
International Classes:
C07D273/01; C07D413/12
Domestic Patent References:
| JP10175966A |
Foreign References:
| WO2015006203A1 |
Attorney, Agent or Firm:
Koichi Hirota
Yoshihiro Nagare
Naoko Matsuda
Yoshihiro Nagare
Naoko Matsuda