Title:
IMPROVED PROCESS FOR PRODUCING 3,4-DIHYDROXYBUTANIC ACID, SALT THEREOF AND LACTONE DERIVED THEREFROM
Document Type and Number:
Japanese Patent JP2005194282
Kind Code:
A
Abstract:
To provide an improved process for preparing 3,4-diyhdroxybutanoic acid applicable to prepare 3,4-dihydroxybutanoic acid-γ-lactone and 2(5H) furanone, particularly, stereoisomers thereof, which are useful as chemical intermediates to naturally occurring fatty acids.
The improved process for converting the D- or L-hexose source to 3,4-diyhdroxybutanoic acid by using an alkali metal or alkaline earth metal hydroxide and a peroxide oxidizing agent is provided. The process comprises maintaining the base and the oxidizing agent <0.02 M in the reaction mixture at any time and maintaining a temperature at about 25-80°C. Upon acidification of the reaction mixture, the 3-hydroxylactone is produced.
Inventors:
HOLLINGSWORTH RAWLE I
Application Number:
JP2005030659A
Publication Date:
July 21, 2005
Filing Date:
February 07, 2005
Export Citation:
Assignee:
UNIV MICHIGAN
International Classes:
C07D307/36; C07C51/09; C07C51/285; C07C59/06; C07C59/10; C07D307/33; C07D315/00; (IPC1-7): C07C51/285; C07C59/06; C07C59/10; C07D307/33
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
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