Title:
IMPROVED PROCESS FOR PRODUCING L-(-)-CARNITINE FROM WASTE HAVING OPPOSITE STERIC CONFIGURATION
Document Type and Number:
Japanese Patent JP3502657
Kind Code:
B2
Abstract:
PURPOSE: To obtain the subject compound useful e.g. for the treatment of cardiac disease and lipid metabolism diseases from waste materials by acylating a precursor of D-(+)-carnitine or the like, lactonizing after acid hydrolysis, treating with a base and subjecting the product to chromatographic treatment.
CONSTITUTION: A precursor of D-(+)-carnitine nitrile of the formula I (X- is an arbitrary counter ion), D-(+)-carnitinamide of the formula II or the like having a configuration reverse to L-(-)-carnitine is converted to acylated compounds expressed by the formula III (R is a 1-12C alkylsulfonyl, formyl or trifluoroacetyl) and the formula IV. The acylated compound is hydrolyzed with an acid, the produced acyl (D)-(+)-carnitine is converted into L-(-)- carnitine lactone of the formula V by the treatment under basic condition, the product is treated in a basic solution to obtain L-(-)-carnitine and the solution is subjected to chromatography on a resin to obtain L-(-)-carnitine in high efficiency from the waste having reverse steric configuration.
Inventors:
Fabio Janessi
Roberto Castagnani
Maria Ornella Chinch
Francesco de Angelis
Paolo de Wit
Domenico Michichi
Roberto Castagnani
Maria Ornella Chinch
Francesco de Angelis
Paolo de Wit
Domenico Michichi
Application Number:
JP6928994A
Publication Date:
March 02, 2004
Filing Date:
April 07, 1994
Export Citation:
Assignee:
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE SOCIETA PER AZIONI
International Classes:
C07B57/00; C07C227/30; C07C227/32; C07C229/22; C07D305/12; C12P13/00; C12P41/00; (IPC1-7): C07C227/30; C07B57/00; C07C229/22
Domestic Patent References:
| JP6306028A | ||||
| JP6199751A | ||||
| JP1287065A |
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)