Title:
IMPROVED REPROGRAMMING METHOD AND CELL CULTURE PLATFORM
Document Type and Number:
Japanese Patent JP2022082668
Kind Code:
A
Abstract:
To provide improved reprogramming methods and cell culture platforms.SOLUTION: The present invention provides compositions and methods for manufacturing pluripotent cells. Particularly, the invention provides improved culture platforms for manufacturing pluripotent cells with ground state pluripotency. In various embodiments, the invention contemplates, in part, a composition comprising: (a) a Wnt pathway agonist; (b) a MEK inhibitor; and (c) a ROCK inhibitor. In certain embodiments, the composition further comprises bFGF or LIF.SELECTED DRAWING: Figure 1E
Inventors:
BAHRAM VALAMEHR
PETER FLYNN
RAMZEY ABUJAROUR
MEGAN ROBINSON
PETER FLYNN
RAMZEY ABUJAROUR
MEGAN ROBINSON
Application Number:
JP2022062448A
Publication Date:
June 02, 2022
Filing Date:
April 04, 2022
Export Citation:
Assignee:
FATE THERAPEUTICS INC
International Classes:
C12N1/00; C07K14/025; C07K14/50; C12N5/0735; C12N5/074; C12N5/0781; C12N5/0787; C12N5/10; C12N15/34; C12Q1/68
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Morishita Natsuki