Title:
IMPROVED SYNTHESIS OF 5ALPHA-CHOLEST-8(14)-EN-3BETA-OL-15-ONE AND OTHER 15-OXYGENATED STEROL
Document Type and Number:
Japanese Patent JP2599255
Kind Code:
B2
Abstract:
PURPOSE: To provide a process to prepare a 15-oxygenated sterol, e.g. 3β- hydroxy-5α-cholest-8(14)-en-15-one.
CONSTITUTION: This process comprises the steps of: converting 7- dehydrocholesterol to 3β-benzoyloxycholesta-5,7-diene, converting this to 3β- benzoyloxycholesta-7,14-diene, further converting this to 3β-benzoyloxy-14α,15α- epoxy-5-cholest-7-ene and converting this 3β-benzoyloxy-14α,15α-epoxy-5-cholest-7- ene to 15-oxygenated sterol.
Inventors:
George Jay Schleffer, Junior
William K. Wilson
K-Shuang
Alemka Sikiku
William K. Wilson
K-Shuang
Alemka Sikiku
Application Number:
JP28072794A
Publication Date:
April 09, 1997
Filing Date:
November 15, 1994
Export Citation:
Assignee:
WILLIAM MARSH RICE UNIVERSITY
International Classes:
C07J9/00; C07J71/00; C07J75/00; (IPC1-7): C07J75/00; C07J9/00
Attorney, Agent or Firm:
Takashi Ishida (2 outside)