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Title:
ＮＩＲ蛍光プローブの改良合成
Document Type and Number:
Japanese Patent JP7077339
Kind Code:
B2
Abstract:
The application relates to a process for the synthesis of a Near Infra-Red (NIR) fluorescent probe which is a cRGD-Cy5.5 conjugate of formula (I) known as DA364 comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety and used in the guided surgery of tumors and pathologic regions.

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Inventors:
Luciano Lattua
Federica Buon Santi
Federico Crivellin
Fulvio Ferretti
Federico Maizano
Laura Orio
Lorena Pittuto
Application Number:
JP2019555792A
Publication Date:
May 30, 2022
Filing Date:
April 10, 2018
Export Citation:
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Assignee:
BRACCO IMAGING S.P.A.
International Classes:
A61K49/00; C07D471/18; C09B23/08
Foreign References:
WO2016097317A1
US20140288300
EP1801086A1
CN102010614A
Other References:
STEFANIA, L. et al.,Contrast Media and Molecular Imaging,2011年,Vol. 6, No. 6,pp. 449 - 458
BAI, M. et al.,Current Medicinal Chemistry,2012年,Vol. 19, No. 28,pp. 4742 - 4758
CHEVALIER, A. et al.,Organic Letters,2014年,Vol. 16, No. 15,pp. 3946 - 3949
Attorney, Agent or Firm:
Yamato Kento
Sei Morimoto
Nobuhiko Akiyama



 
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