Title:
嚢胞性線維症の改良型治療
Document Type and Number:
Japanese Patent JP2009538276
Kind Code:
A
Abstract:
The present invention discloses a therapeutic target for the treatment of cystic fibrosis. It was found that inhibition of non-lysosomal glucosylceramidase (GBA2) sufficiently restores chloride current in cells from CF patients carrying the common delF508-CFTR mutation. With the catalytic center (4) of the enzyme positioned on top of the membrane bilayer face particularly potent inhibitors are found in deoxynojirimycin derivatives having a group that is capable of inserting in the membrane bilayer.
Inventors:
Arts, Johannes Maria Francis Cass Geraldus
Boot, rolf gabriel
Boot, rolf gabriel
Application Number:
JP2009507606A
Publication Date:
November 05, 2009
Filing Date:
April 24, 2007
Export Citation:
Assignee:
Academia Medish Centrum
International Classes:
A61K31/445; A61K45/00; A61K47/48; A61P1/00; A61P11/00; A61P43/00
Foreign References:
| WO2005046672A2 | 2005-05-26 | |||
| WO2005040118A1 | 2005-05-06 | |||
| WO2005046672A2 | 2005-05-26 | |||
| WO2005040118A1 | 2005-05-06 |
Other References:
JPN6012044955; ＦＥＢＳ Ｌｅｔｔｅｒｓ Ｖｏｌ．５８０, 200603, ｐｐ．２０８１-６
JPN6012044955; ＦＥＢＳ Ｌｅｔｔｅｒｓ Ｖｏｌ．５８０, 200603, ｐｐ．２０８１-６
JPN6012044955; ＦＥＢＳ Ｌｅｔｔｅｒｓ Ｖｏｌ．５８０, 200603, ｐｐ．２０８１-６
Attorney, Agent or Firm:
Asamura patent office
Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio
Kajiwara Saiko
Shinmura Morio
Kanamori Koji
Yuko Nagase
Youichi Inoue
Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio
Kajiwara Saiko
Shinmura Morio
Kanamori Koji
Yuko Nagase
Youichi Inoue