Title:
IMPROVEMENT OF HAPTEN USEFUL FOR IMAGE SUBSTANCE AND THERAPEUTIC SUBSTANCE
Document Type and Number:
Japanese Patent JPH021434
Kind Code:
A
Abstract:
NEW MATERIAL: Compounds of formula I (R1 is formula II, formula III, NH-R2, etc.; R2 is H, amino, OC-Y, -P-phenyl-CH-Y, (substituted)alkyl, cycloalkyl, aryl, etc.; Y is EDTA, DTPA, DOTA, HETA, TRITA, TETA; M is a metal ion) or their salts.
USE: Radioactive image substance, radioactive therapeutic substance. The dissociation rate of a hapten-antibody complex and the interaction among hapten, a serum component, and a tissue compartement is changed, and a serum half-life and radiation dosage to the tissue are changed.
PROCESS: For example, a thiourea type compound is obtained by the reaction between an isocyanate precursor and an amine. Isothiocyanate benzyl EDTA and isothiocyanate benzyl DTPA and preferable as isothiocyanate.
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Inventors:
RESURII DEII ANDAASON
JIEEMUZU EMU FURINKU
DEIMON ERU MEIYAA
BURAIAN UIRIAMU SHIYURIBAN
TOOMASU ROBAATO BATAAZUBII
EDOWAADO KUSUNAAZU
JIEEMUZU EMU FURINKU
DEIMON ERU MEIYAA
BURAIAN UIRIAMU SHIYURIBAN
TOOMASU ROBAATO BATAAZUBII
EDOWAADO KUSUNAAZU
Application Number:
JP2652489A
Publication Date:
January 05, 1990
Filing Date:
February 03, 1989
Export Citation:
Assignee:
HYBRITECH INC
International Classes:
A61K31/198; A61K39/395; A61K45/00; A61K49/00; A61K51/04; A61K51/10; A61P35/00; C07C229/16; C07C233/43; C07C233/44; C07C237/04; C07C237/06; C07C237/20; C07C237/52; C07C259/10; C07C275/42; A61K31/195; C07C281/06; C07C323/60; C07C335/20; C07C335/22; (IPC1-7): A61K31/195; A61K39/395; A61K45/00; A61K49/00; C07C229/16; C07C233/43; C07C233/44; C07C237/04; C07C237/20; C07C237/52; C07C259/10; C07C275/42; C07C281/06; C07C323/60; C07C335/20; C07C335/22
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)
Next Patent: 5-SUBSTITUTED ORNITHINE DERIVATIVE