Title:
多能性幹細胞による周産期脳障害の改善及び治療
Document Type and Number:
Japanese Patent JP6994200
Kind Code:
B2
Abstract:
The present invention addresses the problem of providing a novel use of pluripotent stem cells (Muse cells) for medical purposes in regenerative medicine. The present invention provides a cell preparation and a pharmaceutical composition both for ameliorating and treating perinatal brain damage including learning disability and motor disability, each of the cell preparation and the pharmaceutical composition containing SSEA-3-positive pluripotent stem cells isolated from a mesenchymal tissue collected from a living body or cultured mesenchymal cells. The cell preparation according to the present invention relies on a mechanism that Muse cells are administered to a subject having the above-mentioned damage to cause the engraftment of the Muse cells in a damaged brain tissue, thereby ameliorating and treating the damage.
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Inventors:
Yoshiro Sato
Toshihiko Suzuki
Shinobu Shimizu
Mizuno Masaaki
Masahiro Hayakawa
Mari Dezawa
Toshihiko Suzuki
Shinobu Shimizu
Mizuno Masaaki
Masahiro Hayakawa
Mari Dezawa
Application Number:
JP2018518317A
Publication Date:
February 04, 2022
Filing Date:
May 16, 2017
Export Citation:
Assignee:
Tokai National University Organization
Life Science Institute Inc.
Life Science Institute Inc.
International Classes:
A61K35/28; A61P25/00; A61P25/02; A61P25/08; A61P25/14; A61P25/18; A61P25/28
Other References:
SHOKO, N.,Trends in Glycoscience and Glycotechnology,2009年,Vol. 21, No. 120,pp. 207-218
TAKASHI, M. et al.,Trends in Glycoscience and Glycotechnology,2009年,Vol. 21, No. 120,pp. 197-206
加藤稲子,-低酸素性虚血性脳症による脳性麻痺-低酸素性虚血性脳症の治療:先進的治療法,周産期医学,株式会社東京医学社,2013年02月10日,第43巻、第2号,p.208-12,ISSN 0386-9881
杉山裕一朗、外10名,新生児低酸素性虚血性脳症モデルラットにおける間葉系幹細胞療法の検討,再生医療、第15回日本再生医療学会総会プログラム・抄録,2016年02月01日,Vol.15、Suppl,p.261,ISSN 1347-7919
HATTORI, T. et al.,Administration of Umbilical Cord Blood Cells Transiently Decreased Hypoxic-Ischemic Brain Injury in,Dev Neurosci,2015年,Vol.37,p.95-104,ISSN 0378-5866
TAKASHI, M. et al.,Trends in Glycoscience and Glycotechnology,2009年,Vol. 21, No. 120,pp. 197-206
加藤稲子,-低酸素性虚血性脳症による脳性麻痺-低酸素性虚血性脳症の治療:先進的治療法,周産期医学,株式会社東京医学社,2013年02月10日,第43巻、第2号,p.208-12,ISSN 0386-9881
杉山裕一朗、外10名,新生児低酸素性虚血性脳症モデルラットにおける間葉系幹細胞療法の検討,再生医療、第15回日本再生医療学会総会プログラム・抄録,2016年02月01日,Vol.15、Suppl,p.261,ISSN 1347-7919
HATTORI, T. et al.,Administration of Umbilical Cord Blood Cells Transiently Decreased Hypoxic-Ischemic Brain Injury in,Dev Neurosci,2015年,Vol.37,p.95-104,ISSN 0378-5866
Attorney, Agent or Firm:
Aoki Atsushi
Shinji Mihashi
Youichi Watanabe
Nakajima Masaru
Ryotaro Takei
Shinji Mihashi
Youichi Watanabe
Nakajima Masaru
Ryotaro Takei
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