Title:
有機化合物における、またはそれに関する改善
Document Type and Number:
Japanese Patent JP6585605
Kind Code:
B2
Abstract:
A process of converting a carbon-carbon multiple bond to a cyclopropane ring, comprising the addition of a N-alkyl-N-nitroso compound to a mixture of alkene precursor, aqueous base and Pd(II)-catalyst, with the N-alkyl-N-nitroso compound obtained directly from an alkyl amine derivative, NaNO2 and an acid via phase separation of the N-alkyl-N-nitroso compound from the aqueous phase.
Inventors:
Schroeder, Fricchov
Rueti, fabian
Rueti, fabian
Application Number:
JP2016549636A
Publication Date:
October 02, 2019
Filing Date:
October 24, 2014
Export Citation:
Assignee:
Givaudan SA
International Classes:
C07C2/86; C07C13/04; C07C13/28; C07C29/44; C07C33/05; C07C41/30; C07C43/21; C07C45/72; C07C49/553; C07C67/347; C07C69/608
Domestic Patent References:
| JP11209330A | ||||
| JP2009520769A | ||||
| JP62129240A | ||||
| JP9100269A | ||||
| JP2001139545A | ||||
| JP2001151770A |
Foreign References:
| WO2012059485A1 | ||||
| US20120142915 | ||||
| WO2012115118A1 | ||||
| US20120226041 | ||||
| DE4327748A1 | ||||
| WO2005079788A1 |
Other References:
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Microreactors for processing of hazardous and explosible reactions,IChemE Symposium,2007年,(2007) Series No. 153 pp.1-6
Continuous Flow Generation and Reactions of Anhydrous Diazomethane Using a Teflon AF-2400 Tube-in-Tube Reactor,Organic Letters,2013年,2013, 15 (21), pp 5590-5593
Cyclopropanation of Unsaturated Compounds with Diazomethane Generated in situ: A New Efficient and Practical Route to Cyclopropane Derivatives,Mendeleev Communications,1992年,1992, 2, 1, pp.13-15
S-I MURAHASHI; YOSHIMURA Y; YAMAMOTO Y; MORITANI I,QUINTET CARBENES M-PHENYLENEBIS(PHENYLMETHYLENE) AND M-PHENYLENEBIS(METHYLENE),TETRAHEDRON,1972年 1月 1日,VOL:28,PAGE(S):1485 - 1496
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YOVELL J; FELZENSTEIN A; SAREL S,ALCL3-INDUCED REACTIONS OF VINYLCYCLOPROPANES,TETRAHEDRON,PERGAMON PRESS,1978年 1月 1日,VOL:34, NR:7,PAGE(S):993 - 996,URL,http://dx.doi.org/10.1016/0040-4020(78)88153-8
Microreactors for processing of hazardous and explosible reactions,IChemE Symposium,2007年,(2007) Series No. 153 pp.1-6
Continuous Flow Generation and Reactions of Anhydrous Diazomethane Using a Teflon AF-2400 Tube-in-Tube Reactor,Organic Letters,2013年,2013, 15 (21), pp 5590-5593
Cyclopropanation of Unsaturated Compounds with Diazomethane Generated in situ: A New Efficient and Practical Route to Cyclopropane Derivatives,Mendeleev Communications,1992年,1992, 2, 1, pp.13-15
S-I MURAHASHI; YOSHIMURA Y; YAMAMOTO Y; MORITANI I,QUINTET CARBENES M-PHENYLENEBIS(PHENYLMETHYLENE) AND M-PHENYLENEBIS(METHYLENE),TETRAHEDRON,1972年 1月 1日,VOL:28,PAGE(S):1485 - 1496
HAHN R C; CORBIN T F; SHECHTER H,ELECTRICAL EFFECTS OF CYCLOALKYL GROUPS,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,米国,AMERICAN CHEMICAL SOCIETY,1968年 6月19日,VOL:90, NR:13,PAGE(S):3404 - 3415,URL,http://dx.doi.org/10.1021/ja01015a021
PAUL L ORNSTEIN; THOMAS J BLEISCH; BRIAN ARNOLD M; JOSEPH H KENNEDY; REBECCA A WRIGHT; ET AL,JOURNAL OF MEDICINAL CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY,1998年 1月29日,VOL:41, NR:3,PAGE(S):358 - 378,URL,http://dx.doi.org/10.1021/jm970498o
YOSHIHITO OHTAKE; TSUTOMU SATO; HIROHARU MATSUOKA; MASAHIRO NISHIMOTO; NAOKI TAKA; ET AL,BIOORGANIC & MEDICINAL CHEMISTRY,英国,PERGAMON,2011年 8月 3日,VOL:19, NR:18,PAGE(S):5334 - 5341,URL,http://dx.doi.org/10.1016/j.bmc.2011.08.005
GYORGY SZABO; BALAZS VARGA; DORA PAER-LENGYEL; ATTILA SZEMZO; PETER ERDELYI; ET AL,JOURNAL OF MEDICINAL CHEMISTRY,AMERICAN CHEMICAL SOCIETY,2009年 7月23日,VOL:52, NR:14,PAGE(S):4329 - 4337,URL,http://dx.doi.org/10.1021/jm900179y
TAKANORI MATSUDA; MASANORI SHIGENO; MASAHIRO MURAKAMI,CHEMISTRY LETTERS,CHEMICAL SOCIETY OF JAPAN,2006年 1月 1日,VOL:35, NR:3,PAGE(S):288 - 289,IN ,URL,http://dx.doi.org/10.1246/cl.2006.288
ALEXANDRE GAGNON; MARTIN DUPLESSIS; PAMELA ALSABEH; FRANCIS BARAB,PALLADIUM-CATALYZED CROSS-COUPLING REACTION OF TRICYCLOPROPYLBISMUTH WITH ARYL HALIDES AND TRIFLATES,THE JOURNAL OF ORGANIC CHEMISTRY,AMERICAN CHEMICAL SOCIETY,2008年 5月 1日,VOL:73, NR:9,PAGE(S):3604 - 3607,URL,http://dx.doi.org/10.1021/jo702377h
PENG Y; YANG J H; LI W D Z,TETRAHEDRON,NL,ELSEVIER SCIENCE PUBLISHERS,2006年 2月 6日,VOL:62, NR:6,PAGE(S):1209 - 1215,URL,http://dx.doi.org/10.1016/j.tet.2005.10.068
YOVELL J; FELZENSTEIN A; SAREL S,ALCL3-INDUCED REACTIONS OF VINYLCYCLOPROPANES,TETRAHEDRON,PERGAMON PRESS,1978年 1月 1日,VOL:34, NR:7,PAGE(S):993 - 996,URL,http://dx.doi.org/10.1016/0040-4020(78)88153-8
Attorney, Agent or Firm:
Kiyoji Kuzuwa