Title:
胚性幹細胞由来のGABA作動性ニューロンのインビトロ生成および神経疾患の処置におけるその使用
Document Type and Number:
Japanese Patent JP2007520207
Kind Code:
A
Abstract:
The present disclosure is directed to improved methods for efficiently producing neuroprogenitor cells and differentiated neural cells such as GABAergic neurons from pluripotent stem cells, for example embryonic stem cells. Using the disclosed methods, cell populations containing a high proportion of GABAergic neurons have been isolated. The neuroprogenitor cells and terminally differentiated cells of the present disclosure can be generated in large quantities, and therefore may serve as an excellent source for cell replacement therapy in neurodegenerative disorders and neuronal diseases such as stroke, ischemia, epilepsy, and Huntington's disease.
Inventors:
Khan, Fildo Alam
Toti, Satish Maha de Orao
Toti, Satish Maha de Orao
Application Number:
JP2006525210A
Publication Date:
July 26, 2007
Filing Date:
September 02, 2004
Export Citation:
Assignee:
Reliance Life Sun Enzies P-V Tea. Limited
International Classes:
C12N5/0793; C12N5/0789; A61K35/30; A61K35/48; A61L27/00; A61P9/10; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/28
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita