Title:
インビトロ腎毒性スクリーニングアッセイ
Document Type and Number:
Japanese Patent JP7012033
Kind Code:
B2
Abstract:
The invention relates to methods for predicting the in vivo nephrotoxicity of a nucleic acid molecule, in particular a nucleic acid molecule such as a siRNA or an antisense oligonucleotide using an in vitro cell based assay measuring the levels of EGFR as toxicity biomarker, potentially in combination with other biomarkers like ATP and KIM-1.
Inventors:
Gubler Marcel
Moisan Annie
Rohto Adrian Bee.
Moisan Annie
Rohto Adrian Bee.
Application Number:
JP2018565840A
Publication Date:
February 10, 2022
Filing Date:
June 16, 2017
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
A61K31/7088; C12N15/113; A61K48/00; C12Q1/02; C12Q1/68; C40B40/06; G01N33/50; G01N33/68
Domestic Patent References:
| JP2010042019A |
Other References:
Kidney international,2012年,Vol.82,p.45-52
Am J Physiol Renal Physiol,2013年,Vol.304,F356-F366
Am J Physiol Renal Physiol,2013年,Vol.304,F356-F366
Attorney, Agent or Firm:
Shimizu Hatsushi
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto