Title:
酵素ラッカーゼおよびマンガンペルオキシダーゼを用いる異なる種類の化学物質からの生物学的活性化合物の生体内変化
Document Type and Number:
Japanese Patent JP2004501619
Kind Code:
A
Abstract:
A process for the preparation of biologically active compounds, wherein active substances having additional functional groups and a modified spectrum of activity and modified application properties are obtainable from medicinal substances and plant protective agents as substrates which bear at least one amino or hydroxy functional group by using a one-electron reaction catalyzed by enzymes or compositions having enzymatic activity and a broad spectrum of substrates, characterized in that free-radical forming enzymes are employed as enzymes and/or supernatants of ligninolytic fungi in solution are employed as compositions having enzymatic activity, wherein the following can be introduced as additional functional groups: A) polyfunctional synthones which provide the active substance with an altered dissolving behavior in aqueous and lipophilic systems and a high interfacial activity; B) aromatic molecules, heteroaromatic compounds; C) heterocyclic compounds; D) active substances having an independent biological activity; E) active substances combining an independent activity and surfactant properties in one molecule; which yield coupling products being covalently linked with the starting materials and having an altered partition behavior which enable polyfunctional interactions with the target organism.
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Inventors:
Julich Wolf Dieter
Shawell friedel
Lindequist Urrique
Hammer Elke
Schafer Annette
Jonas Ulrique
Shawell friedel
Lindequist Urrique
Hammer Elke
Schafer Annette
Jonas Ulrique
Application Number:
JP2002504666A
Publication Date:
January 22, 2004
Filing Date:
June 23, 2001
Export Citation:
Assignee:
Shawell friedel
Lindequist Urrique
Schafer Annette
Julich Wolf Dieter
Hammer Elke
Jonas Ulrique
Lindequist Urrique
Schafer Annette
Julich Wolf Dieter
Hammer Elke
Jonas Ulrique
International Classes:
A01N43/90; A61K31/43; A61K45/00; A61P31/04; A61P43/00; C07D499/21; C07D499/68; C12P11/00; C12P13/00; C12P17/12; C12P17/14; C12P35/00; C12P37/00; (IPC1-7): C12P35/00; A01N43/90; A61K31/43; A61K45/00; A61P31/04; A61P43/00; C07D499/21; C07D499/68; C12P37/00
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes