Title:
Inactivation of the virus under antibody refining
Document Type and Number:
Japanese Patent JP6023140
Kind Code:
B2
Abstract:
Described herein are methods for isolating and purifying antibodies from a sample matrix. One aspect of the present disclosure is directed to viral reduction/inactivation of samples generated in the various steps of antibody purification. In a particular aspect, methods herein employ an acidification step followed by one or more chromatography steps. The chromatography steps can include one or more of the following chromatographic procedures: ion exchange chromatography, affinity chromatography, and hydrophobic interaction chromatography.
More Like This:
Inventors:
Robert Kay Hickman
Ivan Earl Correia
Ivan Earl Correia
Application Number:
JP2014203181A
Publication Date:
November 09, 2016
Filing Date:
October 01, 2014
Export Citation:
Assignee:
AbbVie Incorporated
International Classes:
C07K1/22; A61K39/395; C07K1/02; C07K1/18; C07K1/20; C07K1/30; C07K1/36; C07K16/24
Domestic Patent References:
| JP9509658A | ||||
| JP2004527212A | ||||
| JP2007528691A |
Foreign References:
| WO2008079280A1 |
Other References:
Journal of Chromatography A,2007年,vol.1176,pp.149-156
Biotechnol Bioeng,2003年,vol.82 no.3,pp.321-329
Journal of Chromatography A,1994年,vol.661,pp.13-23
Biotechnol Bioeng,2003年,vol.82 no.3,pp.321-329
Journal of Chromatography A,1994年,vol.661,pp.13-23
Attorney, Agent or Firm:
Kawaguchi International Patent Office