Title:
INCLUSION COMPLEX AND PRODUCTION THEREOF
Document Type and Number:
Japanese Patent JP3162465
Kind Code:
B2
Abstract:
PURPOSE: To convert apocarotenal and lycopene, i.e., polyenes insoluble in polar solvents, into soluble inclusion complexes and enable them to be effectively utilized in drug administration to human bodies and in coloring by causing them to be included in cyclodextrin.
CONSTITUTION: Cyclodextrin is dissolved in water, a lower alcohol, or a water/ lower alcohol mixture in a ratio of (1:30)-(10:1) in an amt. of 8-10 times that of cyclodextrin. Then, an org. solvent (e.g. chloroform) soln. of apocarotenal or lycopene in an amt. of about (1/10)-(1/10,000) of cyclodextrin is added to the cyclodextrin soln. Methyl-β-cyclodextrin or hydroxypropyl-β-dextrin is used as the cyclodextrin for apocarotenal; and α-cyclodextrin, for lycopene. The org. solvent is removed by distillation, etc., giving a cyclodextrin inclusion complex of apocarotenal or lycopene soluble in a polar solvent.
Inventors:
Brno Leuenberger
Hans Jerg Strer
Hans Jerg Strer
Application Number:
JP6988592A
Publication Date:
April 25, 2001
Filing Date:
February 19, 1992
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
A23L1/275; A61K47/48; C07C11/21; C08B37/16; C07C403/14; C07F13/00; C07G3/00; C07H15/00; (IPC1-7): C08B37/16; C07C11/21; C07C403/14
Other References:
【文献】欧州特許出願公開392608(EP,A2)
Attorney, Agent or Firm:
Heikichi Odashima