Title:
選択的S1P4-アゴニストとしてのインドール-アラニン誘導体
Document Type and Number:
Japanese Patent JP2007518766
Kind Code:
A
Abstract:
The present invention relates to agonists of the S1P4 receptor, which are selective for the S1P4 receptor over one or more of the S1P1, S1P2, S1P3 or S1P5 receptors of at least 10 fold, in particular new indol-alanine derivatives of structure I, process for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them wherein R1 is phenyl or naphthyl, wherein phenyl is substituted by one or two of halogen, C1-6alkyl, C1-6alkoxy or phenylC1-6alkyl; and R2 is hydrogen or C1-6alkyl; in free or salt form.
Inventors:
Kamal Azzaoui
Roshdy Bouelar
Peter Bühlmeier
Danilo Guellini
Manuel Coller
Roshdy Bouelar
Peter Bühlmeier
Danilo Guellini
Manuel Coller
Application Number:
JP2006550040A
Publication Date:
July 12, 2007
Filing Date:
January 20, 2005
Export Citation:
Assignee:
NOVARTIS AG
International Classes:
C07D209/42; A61K31/404; A61P1/04; A61P1/16; A61P3/10; A61P5/14; A61P7/04; A61P7/06; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/02; A61P17/04; A61P17/06; A61P17/14; A61P19/02; A61P21/04; A61P25/00; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/00; A61P31/04; A61P31/12; A61P31/18; A61P35/00; A61P35/02; A61P37/02; A61P37/04; A61P37/06; A61P37/08; A61P39/02; A61P43/00; C12N15/09
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Mitsutaka Iwasaki