Title:
βアミロイド産生および/または凝集と関係がある神経障害および血管障害の処置のためのインドリル-ピロールジオン誘導体
Document Type and Number:
Japanese Patent JP2007509185
Kind Code:
A
Abstract:
The invention relates to the use of an inhibitor of formula (I), or a pharmaceutically acceptable salt thereof having an activity on protein kinases PKC alpha, PKC beta, PKC gamma, PKC epsilon, PKC theta, CDK-1, KDR, PKA, Flt-1, Flt-2, Flt-3 or Flt-4, or on a combination of the above enzymes, for the treatment and/or prevention of neurological and vascular disorders related to beta-amyloid generation and/or aggregation such as neurodegenerative diseases like Down's Syndrome, memory and cognitive impairment, dementia, amyloid neuropathies, brain inflammation, nerve and brain trauma, vascular amyloidosis, or cerebral hemorrhage with amyloidosis.
Inventors:
Eve oberson
Graham Bilb
Rainer El Coon
Peter von Matt
Heinrich Leueger
Matthias Staufen beer
Jürgen Wagner
Caspar Zimmermann
Graham Bilb
Rainer El Coon
Peter von Matt
Heinrich Leueger
Matthias Staufen beer
Jürgen Wagner
Caspar Zimmermann
Application Number:
JP2006537163A
Publication Date:
April 12, 2007
Filing Date:
October 26, 2004
Export Citation:
Assignee:
NOVARTIS AG
International Classes:
A61K45/00; A61K31/00; A61K31/496; A61K31/497; A61K31/517; A61P9/00; A61P25/00; A61P25/28; C07D403/04
Domestic Patent References:
| JPH10287634A | 1998-10-27 |
Foreign References:
| WO2002038561A1 | 2002-05-16 | |||
| WO2002010158A2 | 2002-02-07 | |||
| WO2003082859A1 | 2003-10-09 |
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Mitsutaka Iwasaki